Analysis of variance of standardized observed homozygosity values for cases and controls. S
is the Standardised Observed Homozygosity for an individual genotyped for i loci, calculated as: where N
is the number of homozygote genotypes in the individual concerned and H
is the observed frequency of homozygotes at one of the i loci scored in this individual. ***indicates a highly significant test where P < 1 × 10-5. The IBI + malaria group includes individuals who had invasive bacterial disease but also malaria parasitaemia so that the contribution of the latter to mortality could not be determined with certainty. Sample sizes for the disease classes are as follows: control = 183, bacteraemia = 71, meningitis = 18, neonatal sepsis = 26 and IBI + malaria parasitaemia = 34. IBI: invasive bacterial infection. Error bars are ± 1 standard error.