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Table 4 Risk of acute coronary syndrome in relation to use of NSAID. Aspirin users are included in 'No NSAID'

From: PPARγ Pro12Ala polymorphism and risk of acute coronary syndrome in a prospective study of Danes

PPARγPro12Ala Ncases/Nnon-cases HRa 95% CI HRb 95% CI
Men NSAID NSAID NSAID
  NO YES NO YES NO YES
   Pro/Pro 531/622 58/42 1.00 - 1.63 1.07–2.47 1.00 - 1.58 1.00–2.48
   Pro/Ala 156/190 20/14 0.91 0.75–1.17 1.61 0.79–3.25 0.91 0.70–1.17 1.63 0.79–3.37
   Ala/Ala 20/11 1/1 2.07 0.99–4.32 2.00 0.13–30.5 2.36 1.09–5.13 1.10 0.07–17.7
P for interaction       0.918     0.670
   Pro/Pro 531/622 58/42 1.00 - 1.63 1.07–2.47 1.00 - 1.58 1.00–2.48
Pro/Ala & Ala/Ala 176/201 21/15 0.96 0.77–1.24 1.62 0.72–3.23 0.97 0.76–1.25 1.60 0.79–3.23
P for interaction       0.958     0.929
Women           
   Pro/Pro 145/505 36/76 1.00 - 1.52 0.96–2.41 1.00 - 1.37 0.84–2.23
   Pro/Ala 52/168 10/25 0.99 0.67–1.45 1.31 0.59–2.87 0.93 0.62–1.38 1.33 0.59–3.00
   Ala/Ala 2/9 0/6 0.61 0.12–2.97 - - 0.54 0.11–2.71 - -
P for interaction       0.771     0.924
   Pro/Pro 145/505 36/76 1.00 - 1.42 0.96–2.41 1.00 - 1.36 0.84–2.23
Pro/Ala & Ala/Ala 54/177 10/31 0.96 0.66–1.41 1.08 0.50–2.32 0.90 0.61–1.34 1.14 0.52–2.51
P for interaction       0.517     0.875
  1. a) crude
  2. b) adjusted for smoking status and alcohol consumption