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Table 4 Risk of acute coronary syndrome in relation to use of NSAID. Aspirin users are included in 'No NSAID'

From: PPARγ Pro12Ala polymorphism and risk of acute coronary syndrome in a prospective study of Danes

PPARγPro12Ala

Ncases/Nnon-cases

HRa 95% CI

HRb 95% CI

Men

NSAID

NSAID

NSAID

 

NO

YES

NO

YES

NO

YES

   Pro/Pro

531/622

58/42

1.00

-

1.63

1.07–2.47

1.00

-

1.58

1.00–2.48

   Pro/Ala

156/190

20/14

0.91

0.75–1.17

1.61

0.79–3.25

0.91

0.70–1.17

1.63

0.79–3.37

   Ala/Ala

20/11

1/1

2.07

0.99–4.32

2.00

0.13–30.5

2.36

1.09–5.13

1.10

0.07–17.7

P for interaction

     

0.918

   

0.670

   Pro/Pro

531/622

58/42

1.00

-

1.63

1.07–2.47

1.00

-

1.58

1.00–2.48

Pro/Ala & Ala/Ala

176/201

21/15

0.96

0.77–1.24

1.62

0.72–3.23

0.97

0.76–1.25

1.60

0.79–3.23

P for interaction

     

0.958

   

0.929

Women

          

   Pro/Pro

145/505

36/76

1.00

-

1.52

0.96–2.41

1.00

-

1.37

0.84–2.23

   Pro/Ala

52/168

10/25

0.99

0.67–1.45

1.31

0.59–2.87

0.93

0.62–1.38

1.33

0.59–3.00

   Ala/Ala

2/9

0/6

0.61

0.12–2.97

-

-

0.54

0.11–2.71

-

-

P for interaction

     

0.771

   

0.924

   Pro/Pro

145/505

36/76

1.00

-

1.42

0.96–2.41

1.00

-

1.36

0.84–2.23

Pro/Ala & Ala/Ala

54/177

10/31

0.96

0.66–1.41

1.08

0.50–2.32

0.90

0.61–1.34

1.14

0.52–2.51

P for interaction

     

0.517

   

0.875

  1. a) crude
  2. b) adjusted for smoking status and alcohol consumption