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Table 3 HR for acute coronary syndrome subdivided by alcohol intake and PPARγ Pro12Ala genotype.

From: PPARγ Pro12Ala polymorphism and risk of acute coronary syndrome in a prospective study of Danes

  Ncases/Nnon-cases HR (95% CI)
  Alcohol intake g/day Alcohol intake g/day
PPARγ Pro12Ala < 4.0 4.0 < × < 12.0 > 12.0 < 4.0 4.0 < × < 12.0 > 12.0
Men       
   Pro/Pro 98/81 127/128 364/455 1a 0.86 (0.59–1.28) 0.70 (0.50–0.98)
   Pro/Ala 30/19 41/37 105/148 1.41 (0.73–2.70) 0.90 (0.64–1.55) 0.58 (0.39–0.86)
   Ala/Ala 4/0 4/1 13/11 40.7 (27.5–60.2) 2.30 (0.29–18.5) 1.09 (0.46–2.57)
P for interaction       p < 0.0001
   Pro/Pro 98/81 127/128 364/455 1b 0.91 (0.60–1.37) 0.69 (0.49–0.99)
   Pro/Ala 30/19 41/37 105/148 1.30 (0.67–2.55) 0.78 (0.44–1.39) 0.60 (0.39–0.90)
   Ala/Ala 4/0 4/1 13/11 25.3 (16.5–38.7) 3.18 (0.41–24.8) 1.11 (0.45–2.76)
P for interaction       p < 0.0001
Women       
   Pro/Pro 76/157 50/205 55/219 1a 0.52 (0.34–0.80) 0.52 (0.34–0.79)
   Pro/Ala 25/60 21/63 16/70 0.72 (0.41–1.27) 0.70 (0.39–1.27) 0.45 (0.23–0.88)
   Ala/Ala 1/7 0/4 1/4 0.25 (0.29–2.15) No estimate 0.70 (0.08–6.50)
P for interaction       0.34
   Pro/Pro 76/157 50/205 55/219 1b 0.53 (0.34–0.83) 0.51 (0.33–0.80)
   Pro/Ala 25/60 21/63 16/70 0.73 (0.40–1.31) 0.71 (0.38–1.31) 0.44 (0.22–0.88)
   Ala/Ala 1/7 0/4 1/4 0.27 (0.03–2.15) No estimate 0.52 (0.05–5.30)
P for interaction       0.46
   Pro/Pro 76/157 50/205 55/219 1c 0.53 (0.34–0.84) 0.52 (0.33–0.82)
   Pro/Ala 25/60 21/63 16/70 0.75 (0.41–1.35) 0.72 (0.38–1.35) 0.48 (0.24–0.86)
   Ala/Ala 1/7 0/4 1/4 0.29 (0.03–2.59) No estimate 0.55 (0.05–5.71)
P for interaction       0.51
  1. a) Crude analysis (age adjusted), b) Adjusted for smoking and alcohol intake, c) Adjusted for smoking, alcohol, menopause status and HRT use