PPARγ Pro12Ala polymorphism and risk of acute coronary syndrome in a prospective study of Danes

BMC Medical Genetics

Table 2 Association between PPARγ Pro¹²Ala and risk of acute coronary syndrome among men and women in the Diet, Cancer and Health Cohort

PPARγ Pro¹²Ala	N_case/N_non-cases	HR^a (95% CI)	p	HR^b (95% CI)	p	HR^c (95% CI)	p
Men
Pro/Pro	589/664	1.0		1.0
Pro/Ala	176/204	0.92 (0.73–1.17)	0.51	0.92 (0.72–1.18)	0.50	Not relevant
Ala/Ala	21/12	1.99 (0.98–4.05)	0.06	2.12 (1.00–4.48)	0.05	Not relevant
Pro/Ala & Ala/Ala	197/216	0.98 (0.78–1.23)	0.86	0.98 (0.77–1.24)	0.86	Not relevant
Women
Pro/Pro	181/581	1.0		1.0		1.0
Pro/Ala	62/193	0.96 (0.67–1.36)	0.80	0.93 (0.65–1.35)	0.75	0.96 (0.67–1.40)	0.85
Ala/Ala	2/15	0.38 (0.08–1.72)	0.21	0.37 (0.08–1.72)	0.21	0.40 (0.08–1.85)	0.24
Pro/Ala & Ala/Ala	64/208	0.91 (0.65–1.29)	0.60	0.89 (0.62–1.27)	0.53	0.92 (0.64–1.33)	0.60

a) Crude (only adjusted for age)
b) Adjusted for alcohol, smoking and NSAID
c) Adjusted for alcohol, smoking, NSAID, hormone replacement therapy and menopause status

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