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Table 2 Association between PPARγ Pro12Ala and risk of acute coronary syndrome among men and women in the Diet, Cancer and Health Cohort

From: PPARγ Pro12Ala polymorphism and risk of acute coronary syndrome in a prospective study of Danes

PPARγ Pro12Ala Ncase/Nnon-cases HRa (95% CI) p HRb (95% CI) p HRc (95% CI) p
Men        
   Pro/Pro 589/664 1.0   1.0    
   Pro/Ala 176/204 0.92 (0.73–1.17) 0.51 0.92 (0.72–1.18) 0.50 Not relevant  
   Ala/Ala 21/12 1.99 (0.98–4.05) 0.06 2.12 (1.00–4.48) 0.05 Not relevant  
   Pro/Ala & Ala/Ala 197/216 0.98 (0.78–1.23) 0.86 0.98 (0.77–1.24) 0.86 Not relevant  
Women        
   Pro/Pro 181/581 1.0   1.0   1.0  
   Pro/Ala 62/193 0.96 (0.67–1.36) 0.80 0.93 (0.65–1.35) 0.75 0.96 (0.67–1.40) 0.85
   Ala/Ala 2/15 0.38 (0.08–1.72) 0.21 0.37 (0.08–1.72) 0.21 0.40 (0.08–1.85) 0.24
   Pro/Ala & Ala/Ala 64/208 0.91 (0.65–1.29) 0.60 0.89 (0.62–1.27) 0.53 0.92 (0.64–1.33) 0.60
  1. a) Crude (only adjusted for age)
  2. b) Adjusted for alcohol, smoking and NSAID
  3. c) Adjusted for alcohol, smoking, NSAID, hormone replacement therapy and menopause status