First author, Year, Country [ref] | Study design, duration of FU | Cohort description [No of patients (M/F), Ethnicity, Mean Age (SD), inclusion criteria] | Restenosis definition criteria | Intervention | Gene-gene interaction assessed? (gene) | Quality score |
---|---|---|---|---|---|---|
 |  |  |  | Balloon angioplasty |  |  |
Volzke, 2000, Germany [17] | cohort 6 months | 511 (388/123), Caucasians, 60.6 (8.6), CAD patients undergoing elective PTCA of a previously untreated native coronary artery | > 50% progression of the residual stenosis at FU | PTCA-balloon | No | 35 |
Yoshida, 1999, Japan [18] | cohort 5.21 (3.9) years | 123 (nr), East Asians, 58.2 (10.2), MI patients undergoing PTCA discharged from hospital at the start of FU | nr | PTCA-balloon | No | 30 |
Kasi, 1996, Spain [19] | cohort 6 months | 69 (57/12), Caucasians, 58 (9.9), UA patients undergoing PTCA | diameter stenosis > 50% at FU | PTCA-balloon | No | 27 |
Kamitani, 1995, Japan [20] | cohort 6 months | 103 (103/00), East Asians, 52 (1), Primary PTCA for MI patients | > 50% progression of the residual stenosis at FU | PTCA-balloon | No | 27 |
Samani, 1995, UK [21] | cohort 4 months | 233 (194/39), nr, 56 (1), single-vessel PTCA in the Subcutaneous Heparin and Angioplasty Restenosis Prevention (SHARP) study | > 50% progression of the residual stenosis at FU | PTCA-balloon | No | 34 |
van Bockxmeer, 1995, Australia [22] | cohort 6 months | 207 (170/37), Caucasians, 57 (9), CAD patients undergoing elective PTCA | > 50% progression of the residual stenosis at FU | PTCA-balloon | Yes (APOE) | 33 |
Tsukada, 1997, Japan [23] | cohort 3 months | 96 (nr), East Asians, 60 (1.0), CAD patients undergoing elective PTCA | diameter stenosis > 50% at FU | PTCA-balloon | No | 28 |
Beohar, 1995, USA [24] | cohort 3 months | 89 (nr), Caucasians, 63.9 (10), CAD patients undergoing elective PTCA | diameter stenosis > 50% at FU | PTCA-balloon | No | 24 |
Zee, 2001, Spain [25] | cohort 6 months | 342 (305/37), Caucasians, 58.9 (9.6), CAD patients undergoing PTCA | > 50% progression of the residual stenosis at FU | PTCA-balloon | No | 37 |
Ohishi, 1993, Japan [26] | cohort 6 months | 82 (nr), East Asians, nr, MI patients undergoing primary PTCA | > 50% progression of the residual stenosis at FU | PTCA-balloon | No | 23 |
Hamon, 1998, France [37] | cohort 6 months | 271 (229/42), Caucasians, 60 (10), CAD patients undergoing PTCA | diameter stenosis > 50% at FU | PTCA-balloon | Yes (AGT1R) | 34 |
 |  |  |  | Angioplasty with stent deployment |  |  |
Amant, 1997, France [30] | cohort 6 months | 146 (117/29), Caucasians, 60 (10) CAD patients undergoing PTCA | diameter stenosis > 50% at FU | PTCA-STENT | No | 37 |
Wijpkema, 2006, Netherlands [29] | cohort 9 months | 2888 (2050/838), Caucasians, 62 (11), CAD patients undergoing elective PTCA | death from cardiac causes, MI attributable to target vessel and target vessel revascularization | PTCA-STENT | Yes (AGT, AGT1R, AGT2R, HMOX1) | 35 |
Gomma, 2002, UK [31] | cohort 6 months | 205 (155/50), Caucasians, 59.4 (9.9), CAD patients undergoing PTCA | diameter stenosis > 50% at FU | PTCA-STENT | No | 27 |
Ruy, 2002, Korea [32] | cohort 6 months | 238 (178/60), East Asians, 59.5 (9.9), CAD patients undergoing PTCA | diameter stenosis > 50% at FU | PTCA-STENT | Yes (CYP11B2, AGT) | 32 |
Ribichini, 2004, Italy [33] | cohort 6 months | 897 (160/737), Caucasians, 61 (10), CAD patients undergoing PTCA | diameter stenosis > 50% at FU | PTCA-STENT | No | 33 |
Taniguchi, 2001, Japan [34] | cohort 6 months | 67 (50/17), East Asians, 65.2 (9.7), CAD patients undergoing PTCA | > 50% progression of the residual stenosis at FU | PTCA-STENT | No | 23 |
Koch, 2000, Germany [35] | cohort 1 year | 1850 (1458/392), Caucasians, 62.9 (10), CAD patients undergoing PTCA | diameter stenosis > 50% at FU | PTCA-STENT | No | 40 |
Gurlek, 2000, Turkey [36] | cohort 6 months | 132 (112/20), Turks, 53 (9), CAD patients undergoing PTCA | diameter stenosis > 50% at FU | PTCA-STENT | No | 29 |
Guneri, 2005, Turkey [43] | cohort 9 months (2.9) | 94 (59/35), Turks, 59.6 (9.9), CAD diabetic patients undergoing PTCA for stable angina pectoris | diameter stenosis > 50% at FU | PTCA-STENT | No | 26 |
 |  |  |  | Angioplasty with ACEi treatment |  |  |
Ribichini, 2003, Italy [42] | Cohort 6.3 (2.5) months | 271 (nr), Caucasians, 61 (10), CAD patients undergoing PTCA | diameter stenosis > 50% at FU | PTCA-STENT + ACEi | No | 35 |
Okamura, 1999, Japan [44] | cohort 6 months | 97 (84/13), East Asians, 60 (2), CAD patients undergoing PTCA for stable angina pectoris | diameter stenosis > 50% at FU | PTCA-balloon + Imidapril 5 mg | No | 29 |
Okumura, 2002, Japan [45] | cohort 6 months | 92 (73/19), East Asians, 64.3 (8.9), CAD patients undergoing PTCA | diameter stenosis > 50% at FU | PTCA-STENT + Quinapril 18 mg | No | 22 |
Ferrari, 2002, multicenter (Europe) [46] | cohort 6 months | 154 (119/35), Caucasians, 61 (9.9), CAD patients undergoing PTCA | > 50% progression of the residual stenosis at FU | PTCA-STENT + ACEi | No | 36 |
Jorgensen, 2001, Netherlands [49] | cohort 6 months | 369 (293/76), Caucasians, 59 (43–73), CAD patients undergoing PTCA for stable angina | diameter stenosis > 50% at FU | PTCA-STENT + ACEi | No | 40 |