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Table 4 Results (as P values) from the validation study genotyping and association analyses for the Caucasian sample, including GWAS cases and controls.*

From: Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: The HyperGEN Study

   GWAS Cases and Controls (101 pairs) Caucasians (N = 906)
(With GWAS cases & controls)
  
SNP Chr P Log(LVMI) LVH MAF Nearest
Object
Distance (Mb)
rs409045 5p13.3 8.47E-07 0.0015 0.0006 0.38 RAI14 0.028
rs6450415 5q11.2 6.43E-05 0.075 0.068 0.45 FLJ35954 0.10
rs1833534 5q34 9.62E-05 0.0063 0.0118 0.13 CCNG1 0.044
rs6961069 7q21 7.34E-05 0.062 0.56 0.41 SEMA3C 0.040
rs10499859 7q21 3.27E-06 0.091 0.56 0.45 CD36 0.15
rs4129000 12q14.3 2.26E-05 < 0.0001 0.0002 0.16 LOC729298 0.095
rs4129218 12q13.3 5.19E-05 < 0.0001 0.0001 0.21 LOC729298 0.10
rs1155635 13q21.33 9.09E-05 0.024 0.0041 0.38 KLHL1 0.27
rs238688 20p13 8.33E-05 0.56 0.66 0.27 ATRN Intron
rs756529 20q13.13 9.10E-05 0.36 0.18 0.41 KCNB1 Intron
rs10483186 22q12 3.12E-05 0.065 0.38 0.46 LOC91464 0.12
  1. *Analysis adjusted for age, sex, weight, systolic blood pressure, and diabetes; Chr = chromosome; GWAS = genome-wide association study; LVMI = left ventricular mass index defined as LV mass/height2.7; LVH = left ventricular hypertrophy defined as LVMI > 47 g/m2.7 in women and > 50 g/m2.7 in men; MAF = Overall frequency of carriers of minor allele (homozygotes + heterozygotes); SNP = single-nucleotide polymorphism