Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: The HyperGEN Study

Table 3 Results (as P values) from the validation study genotyping and association analyses for the Caucasian sample, not including GWAS cases and controls.*

		GWAS Cases and Controls (101 pairs)	Caucasians (N = 704) (No GWAS cases & controls)
SNP	Chr	P	Log(LVMI)	LVH	MAF	Nearest object	Distance (Mb)
rs409045	5p13.3	8.47E-07	0.0101	0.0798	0.39	RAI14	0.028
rs6450415	5q11.2	6.43E-05	0.51	0.98	0.45	FLJ35954	0.10
rs1833534	5q34	9.62E-05	0.49	0.54	0.12	CCNG1	0.044
rs6961069	7q21	7.34E-05	0.97	0.38	0.41	SEMA3C	0.040
rs10499859	7q21	3.27E-06	0.65	0.22	0.45	CD36	0.15
rs4129000	12q14.3	2.26E-05	0.035	0.18	0.16	LOC729298	0.095
rs4129218	12q13.3	5.19E-05	0.007	0.038	0.21	LOC729298	0.10
rs1155635	13q21.33	9.09E-05	0.92	0.57	0.39	KLHL1	0.27
rs238688	20p13	8.33E-05	0.31	0.59	0.27	ATRN	Intron
rs756529	20q13.13	9.10E-05	0.74	0.32	0.41	KCNB1	Intron
rs10483186	22q12	3.12E-05	0.55	0.086	0.46	LOC91464	0.12

*Analysis adjusted for age, sex, weight, systolic blood pressure, and diabetes; Chr = chromosome; GWAS = genome-wide association study; LVMI = left ventricular mass index defined as LV mass/height^2.7; LVH = left ventricular hypertrophy defined as LVMI > 47 g/m^2.7 in women and > 50 g/m^2.7 in men; MAF = Overall frequency of carriers of minor allele (homozygotes + heterozygotes); SNP = single-nucleotide polymorphism

ISSN: 1471-2350