Table 1 Demographic and clinical characteristics by case-control status and validation study population.
Genome-wide association | Validation study | ||||
|---|---|---|---|---|---|
Characteristics | Case (N = 101) | Control (N = 101) | P* | Caucasians (N = 704) | African Americans (N = 1467) |
Age, years | 59.1 ± 9.1 | 60.3 ± 9.3 | 0.34 | 60.7 ± 8.34 | 50.8 ± 11.0 |
Females, % | 66.3 | 66.3 | 1.00 | 48.9 | 64.4 |
Diabetic, % | 19.8 | 12.9 | 0.18 | 15.8 | 22.8 |
Weight, kg† | 90.1 (70.9 – 114.4) | 79.6 (64.2 – 98.7) | 0.0001 | 85.5 ± 17.8 | 89.9 ± 21.5 |
Height, cm | 164.6 ± 8.0 | 169.0 ± 8.7 | 0.0002 | 168.9 ± 9.1 | 167.3 ± 9.1 |
Body mass index, kg/m2† | 33.4 (26.7 – 41.8) | 27.9 (23.3 – 33.5) | < 0.0001 | 29.9 ± 5.5 | 32.2 ± 7.5 |
Percentage of body fat‡ | 39.3 ± 8.9 | 36.0 ± 8.2 | 0.012 | 35.3 ± 8.6 | 39.9 ± 9.5 |
Systolic blood pressure, mm Hg | 135.5 ± 20.8 | 126.1 ± 15.7 | 0.0003 | 126.8 ± 20.2 | 132.1 ± 22.5 |
Diastolic blood pressure, mm Hg | 70.9 ± 12.5 | 71.0 ± 10.2 | 0.90 | 70.1 ± 10.6 | 75.2 ± 11.7 |
Pulse pressure, mm Hg | 64.7 ± 16.2 | 55.1 ± 13.7 | < 0.0001 | 56.7 ± 16.2 | 56.9 ± 16.7 |
Postural SBP change, mm Hg | -1.32 ± 14.7 | -0.91 ± 15.0 | 0.85 | -2.55 ± 14.8 | 1.63 ± 14.2 |
Hypertension status | |||||
Normal BP, % | 0.0 | 0.0 | - | 22.9 | 13.5 |
Mild hypertension, % | 42.6 | 57.4 | - | 35.2 | 37.4 |
Severe hypertension, % | 57.4 | 42.6 | - | 41.9 | 49.1 |
Antihypertensive drugs, N | 1.43 ± 0.84 | 1.35 ± 0.71 | 0.42 | 1.38 ± 0.80 | 1.35 ± 0.92 |
LV mass, g | 214.5 ± 32.8 | 130.3 ± 21.8 | < 0.0001 | 171.7 ± 40.5 | 178.1 ± 49.8 |
LV mass/body surface area, g/m2 | 108.9 ± 15.0 | 68.0 ± 9.0 | < 0.0001 | 87.6 ± 17.3 | 89.9 ± 22.7 |
LV mass/height2.7, g/m2.7 | 56.2 ± 6.3 | 31.4 ± 3.9 | < 0.0001 | 41.6 ± 8.66 | 44.4 ± 12.1 |
Urinary albumin:creatinine ratio† | 6.87 (1.93 – 24.4) | 3.11 (0.58 – 16.6) | 0.0002 | 3.74 (0.92 – 15.2) | 7.24 (1.27 – 41.3) |