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Table 1 Demographic and clinical characteristics by case-control status and validation study population.

From: Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: The HyperGEN Study

  Genome-wide association Validation study
Characteristics Case
(N = 101)
Control
(N = 101)
P* Caucasians (N = 704) African Americans
(N = 1467)
Age, years 59.1 ± 9.1 60.3 ± 9.3 0.34 60.7 ± 8.34 50.8 ± 11.0
Females, % 66.3 66.3 1.00 48.9 64.4
Diabetic, % 19.8 12.9 0.18 15.8 22.8
Weight, kg 90.1 (70.9 – 114.4) 79.6 (64.2 – 98.7) 0.0001 85.5 ± 17.8 89.9 ± 21.5
Height, cm 164.6 ± 8.0 169.0 ± 8.7 0.0002 168.9 ± 9.1 167.3 ± 9.1
Body mass index, kg/m2† 33.4 (26.7 – 41.8) 27.9 (23.3 – 33.5) < 0.0001 29.9 ± 5.5 32.2 ± 7.5
Percentage of body fat 39.3 ± 8.9 36.0 ± 8.2 0.012 35.3 ± 8.6 39.9 ± 9.5
Systolic blood pressure, mm Hg 135.5 ± 20.8 126.1 ± 15.7 0.0003 126.8 ± 20.2 132.1 ± 22.5
Diastolic blood pressure, mm Hg 70.9 ± 12.5 71.0 ± 10.2 0.90 70.1 ± 10.6 75.2 ± 11.7
Pulse pressure, mm Hg 64.7 ± 16.2 55.1 ± 13.7 < 0.0001 56.7 ± 16.2 56.9 ± 16.7
Postural SBP change, mm Hg -1.32 ± 14.7 -0.91 ± 15.0 0.85 -2.55 ± 14.8 1.63 ± 14.2
Hypertension status      
   Normal BP, % 0.0 0.0 - 22.9 13.5
   Mild hypertension, % 42.6 57.4 - 35.2 37.4
   Severe hypertension, % 57.4 42.6 - 41.9 49.1
Antihypertensive drugs, N 1.43 ± 0.84 1.35 ± 0.71 0.42 1.38 ± 0.80 1.35 ± 0.92
LV mass, g 214.5 ± 32.8 130.3 ± 21.8 < 0.0001 171.7 ± 40.5 178.1 ± 49.8
LV mass/body surface area, g/m2 108.9 ± 15.0 68.0 ± 9.0 < 0.0001 87.6 ± 17.3 89.9 ± 22.7
LV mass/height2.7, g/m2.7 56.2 ± 6.3 31.4 ± 3.9 < 0.0001 41.6 ± 8.66 44.4 ± 12.1
Urinary albumin:creatinine ratio 6.87 (1.93 – 24.4) 3.11 (0.58 – 16.6) 0.0002 3.74 (0.92 – 15.2) 7.24 (1.27 – 41.3)
  1. *P for comparison of means between cases and controls; Reported as geometric mean (SD range) because natural-log transformed values were compared between cases and controls; Lukaski equation; SBP = systolic blood pressure