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Table 5 Peak Multipoint LOD Scores and Flanking Markers for Regions with LOD > 2.0 from at Least One Adjustment Model in African Americans and Whites

From: Identification of a pleiotropic locus on chromosome 7q for a composite left ventricular wall thickness factor and body mass index: the HyperGEN Study

Trait

Model

Chr

Pos (cM*)

LOD/p†

Flanking Markers (cM*)

African Americans

     

   IVSTd

Min

21

37

1.32/0.0066

ATA27F01 (37)

   IVSTd

Max1

21

38

2.17/0.0005

ATA27F01 (37)/GATA188F04 (40)

   LVIDd

Min

3

36

2.30/0.0006

AFM036YB8 (37)

   LVIDd

Max1

3

36

2.16/0.0012

AFM036YB8 (37)

   LVM

Min

12

18

1.18/0.0109

GATA49D12 (18)

   LVM

Max1

12

19

2.13/0.0011

GATA49D12 (18)/GATA11H08 (26)

   LVM

Max3

12

18

1.54/0.0051

GATA49D12 (18)

Whites

     

   LVM

Min

2

170

2.40/0.0004

ATA27H09 (165)/GATA71D01 (173)

   LVM

Max1

2

169

1.96/0.0010

ATA27H09 (165)/GATA71D01 (173)

   LVM

Max3

2

170

1.94/0.0011

ATA27H09 (165)/GATA71D01 (173)

   LVM

Min

4

43

2.34/0.0004

ATA27C07 (43)

   LVM

Max1

4

43

1.79/0.0019

ATA27C07 (43)

   LVM

Max3

4

43

1.86/0.0016

ATA27C07 (43)

   PWTd

Min

7

161

2.51/0.0003

D7S2195 (155)/GATA189C06 (163)

   PWTd

Max1

7

162

1.59/0.0028

D7S2195 (155)/GATA189C06 (163)

   LV wall thickness factor

Min

7

160

3.12/0.0002

D7S2195 (155)/GATA189C06 (163)

   LV wall thickness factor

Max1

7

161

2.24/0.0008

D7S2195 (155)/GATA189C06 (163)

   MVA

Min

1

144

3.42/0.00005

ATA29D04 (137)/GATA12A07 (152)

   MVA

Max2

1

141

2.32/0.0006

ATA29D04 (137)/GATA12A07 (152)

   MVA

Min

3

26

2.28/0.0005

GATA164B08 (26)

   MVA

Max2

3

27

2.94/0.0002

GATA164B08 (26)

   MVA

Min

5

148

2.56/0.0003

ATA23A10 (148)

   MVA

Max2

5

148

2.05/0.0012

ATA23A10 (148)

   MVA

Min

10

72

2.17/0.0008

ATA5A04 (63)/AFM329xa9 (76)

   MVA

Max2

10

92

2.35/0.0006

GATA121A08 (88)/GATA87G01 (94)

   MVA

Min

17

54

2.13/0.0008

GGAA9D03 (51)/GGAA7D11 (57)

   MVA

Max2

17

55

2.27/0.0007

GGAA9D03 (51)/GGAA7D11 (57)

   LV diastolic filling factor

Min

10

28

2.05/0.0017

ATA31G11 (28)

   LV diastolic filling factor

Max2

10

28

1.85/0.0024

ATA31G11 (28)

  1. IVSTd = interventricular septal thickness at end-diastole, LVIDd = LV internal diameter at end-diastole, LVM = LV mass, MVA = LV transmitral atrial phase peak filling velocity, PWTd = LV diastolic posterior wall thickness; *in Kosambi distance; †empirical p value based on simulation;
  2. Min: adjusted for age, age2, and gender;
  3. Max1: additionally adjusted for BMI, SBP, diabetes, and current smoking;
  4. Max2: additionally adjusted for heart rate, BMI, SBP, diabetes, and current smoking;
  5. Max3: additionally adjusted for BMI.