Skip to main content

Table 3 Association between three non-synonymous polymorphisms in TRPM6 and TRPM7 and the risk of type 2 diabetes among women stratified by magnesium intake

From: Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women

   

Magnesium Intake

 

Number

Low

(<250 mg/day)

High

(≥ 250 mg/day)

Genotype a

Cases

Controls

Age, race, and BMI-adjusted OR (95% CI)

Multivariate-adjusted OR (95% CI)b

Age, race, and BMI-adjusted OR

(95% CI)

Multivariate-adjusted OR (95% CI)b

TRPM6

      

rs3750425 (Val1393Ile)

GG

279

287

1.00

1.00

1.00

1.00

GA/AA

60

64

4.32

(0.98–19.1)

5.29

(0.96–29.1)

0.90

(0.57–1.44)

0.80

(0.49–1.31)

rs2274924 (Lys1584Glu)

      

AA

239

230

1.00

1.00

1.00

1.00

AG/GG

106

114

2.19

(0.68–7.11)

2.16

(0.58–8.07)

0.89

(0.61–1.31)

0.88

(0.59–1.31)

Haplotypec

      

0–0 (G-A)

82.4%

81.5%

1.00

1.00

1.00

1.00

1–1 (A-G)

9.86%

9.30%

4.92

(1.05–23.0)

5.80

(1.01–33.5)

0.95

(0.62–1.44)

0.87

(0.56–1.35)

0–1 (G-G)

7.72%

9.03%

0.56

(0.09–3.52)

0.44

(0.06–3.26)

0.94

(0.61–1.46)

1.03

(0.66–1.63)

TRPM7

      

rs8042919 (Thr1482Ile)

GG

278

272

1.00

1.00

1.00

1.00

AG/AA

63

76

2.48

(0.48–12.7)

3.60

(0.56–23.0)

0.93

(0.60–1.44)

0.97

(0.61–1.52)

  1. a: Only haplotypes with frequency > 1% are reported
  2. b: Adjusted for matching variables (age and race), BMI, smoking, alcohol use, exercise, and family history of diabetes.
  3. c: Haplotypes (rs3750425/rs2274924) were inferred from phase-unknown genotype data using the expectation-maximization algorithm.