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Table 4 Hazard ratios (HR) for total and cardiac mortality according to HMOX1 genotypes and haplotypes.

From: Genetic variants of the promoter of the heme oxygenase-1 gene and their influence on cardiovascular disease (The Ludwigshafen Risk and Cardiovascular Health Study)

 

HR (95% CI)

Total*

P

HR (95% CI)

Cardiac*

P

A>T rs2071746

    

AA

1.0reference

 

1.0reference

 

AT1

0.99 (0.84–1.16)

0.886

1.06 (0.87–1.29)

0.569

TT1

0.96 (0.78–1.19)

0.727

0.95 (0.73–1.26)

0.734

AA vs AT or TT1

0.97 (0.80–1.18)

0.746

0.92 (0.72–1.18)

0.519

AA or AT vs TT1

0.98 (0.85–1.14)

0.818

1.03 (0.86–1.25)

0.739

VNTR S<25, L ≥ 25

    

SS

1.0reference

 

1.0reference

 

SL1

1.08 (0.84–1.40)

0.543

1.12 (0.81–1.54)

0.501

LL1

1.08 (0.84–1.39)

0.569

1.02 (0.74–1.40)

0.922

SS vs SL or LL1

1.08 (0.85–1.38)

0.536

1.06 (0.79–1.44)

0.688

SS or SL vs LL1

1.01 (0.87–1.16)

0.910

0.93 (0.77–1.11)

0.423

  1. 1Genotypes treated as categorical variables and compared to the reference category.
  2. *adjusted for age, and sex.