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Table 3 Odds ratios (OR) for angiographic CAD according to HMOX1 genotypes and haplotypes.

From: Genetic variants of the promoter of the heme oxygenase-1 gene and their influence on cardiovascular disease (The Ludwigshafen Risk and Cardiovascular Health Study)

  Model 1
OR (95% CI)
P Model 2
OR (95% CI)
P Model 3
OR (95% CI)
P
A>T rs2071746       
AA 1.0reference   1.0reference   1.0reference  
AT 0.95 (0.79–1.15) 0.619 0.92 (0.76–1.12) 0.398 1.03 (0.82–1.30) 0.788
TT 1.18 (0.91–1.52) 0.215 1.16 (0.89–1.52) 0.282 1.27 (0.93–1.73) 0.142
AA vs AT vs TT2 1.06 (0.94–1.19) 0.363 1.04 (0.92–1.19) 0.506 1.11 (0.95–1.28) 0.190
AA vs AT or TT1 1.21 (0.96–1.52) 0.110 1.22 (0.95–1.55) 0.115 1.24 (0.94–1.65) 0.135
AA or AT vs TT1 1.01 (0.84–1.20) 0.963 0.98 (0.81–1.17) 0.789 1.09 (0.88–1.35) 0.455
VNTR S<25, L ≥ 25       
SS 1.0reference   1.0reference   1.0reference  
SL1 0.82 (0.61–1.10) 0.183 0.76 (0.56–1.05) 0.086 0.70 (0.49–1.019 0.056
LL1 0.83 (0.62–1.12) 0.217 0.80 (0.59–1.09) 0.153 0.71 (0.49–1.02) 0.063
SS vs SL vs LL2 0.95 (0.84–1.08) 0.407 0.95 (0.83–1.09) 0.413 0.90 (0.77–1.05) 0.187
SS vs SL or LL1 0.82 (0.62–1.09) 0.180 0.78 (0.58–1.05) 0.100 0.71 (0.50–1.00) 0.049
SS or SL vs LL1 0.98 (0.83–1.16) 0.787 0.99 (0.83–1.19) 0.945 0.95 (0.77–1.16) 0.592
  1. 1Genotypes treated as categorical variables and compared to the reference category.
  2. 2Genotypes treated as interval-scaled variables.
  3. Model 1: unadjusted.
  4. Model 2: adjusted for age, and sex.
  5. Model 3: in addition adjusted for clinical status at presentation (no CAD, stable CAD, unstable CAD, NSTEMI, STEMI), body mass index, metabolic syndrome/diabetes mellitus, hypertension, smoking, LDL cholesterol, HDL cholesterol, triglycerides (log transformed), SAA, use of betablockers, use of lipid lowering drugs.