Genetic variants of the promoter of the heme oxygenase-1 gene and their influence on cardiovascular disease (The Ludwigshafen Risk and Cardiovascular Health Study)

Table 3 Odds ratios (OR) for angiographic CAD according to HMOX1 genotypes and haplotypes.

	Model 1 OR (95% CI)	P	Model 2 OR (95% CI)	P	Model 3 OR (95% CI)	P
A>T rs2071746
AA	1.0^reference		1.0^reference		1.0^reference
AT	0.95 (0.79–1.15)	0.619	0.92 (0.76–1.12)	0.398	1.03 (0.82–1.30)	0.788
TT	1.18 (0.91–1.52)	0.215	1.16 (0.89–1.52)	0.282	1.27 (0.93–1.73)	0.142
AA vs AT vs TT²	1.06 (0.94–1.19)	0.363	1.04 (0.92–1.19)	0.506	1.11 (0.95–1.28)	0.190
AA vs AT or TT¹	1.21 (0.96–1.52)	0.110	1.22 (0.95–1.55)	0.115	1.24 (0.94–1.65)	0.135
AA or AT vs TT¹	1.01 (0.84–1.20)	0.963	0.98 (0.81–1.17)	0.789	1.09 (0.88–1.35)	0.455
VNTR S<25, L ≥ 25
SS	1.0^reference		1.0^reference		1.0^reference
SL¹	0.82 (0.61–1.10)	0.183	0.76 (0.56–1.05)	0.086	0.70 (0.49–1.019	0.056
LL¹	0.83 (0.62–1.12)	0.217	0.80 (0.59–1.09)	0.153	0.71 (0.49–1.02)	0.063
SS vs SL vs LL²	0.95 (0.84–1.08)	0.407	0.95 (0.83–1.09)	0.413	0.90 (0.77–1.05)	0.187
SS vs SL or LL¹	0.82 (0.62–1.09)	0.180	0.78 (0.58–1.05)	0.100	0.71 (0.50–1.00)	0.049
SS or SL vs LL¹	0.98 (0.83–1.16)	0.787	0.99 (0.83–1.19)	0.945	0.95 (0.77–1.16)	0.592

¹Genotypes treated as categorical variables and compared to the reference category.
²Genotypes treated as interval-scaled variables.
Model 1: unadjusted.
Model 2: adjusted for age, and sex.
Model 3: in addition adjusted for clinical status at presentation (no CAD, stable CAD, unstable CAD, NSTEMI, STEMI), body mass index, metabolic syndrome/diabetes mellitus, hypertension, smoking, LDL cholesterol, HDL cholesterol, triglycerides (log transformed), SAA, use of betablockers, use of lipid lowering drugs.

ISSN: 1471-2350