Genetic variants of the promoter of the heme oxygenase-1 gene and their influence on cardiovascular disease (The Ludwigshafen Risk and Cardiovascular Health Study)

Table 2 Prevalence of HMOX1 genotypes and haplotypes in CAD patients and controls.

HMOX1 genotype	Controls		CAD		P ¹
	N	%	N	%
A>T rs2071746
AA	246	35.5	893	35.4
AT	341	49.2	1181	46.8
TT	106	15.3	452	17.9	0.245
A allele	833	60.1	2967	58.7
T allele	553	39.9	2085	41.3	0.358
VNTR S <25, L ≥ 25 repeats
SS	66	9.5	286	11.3
SL	302	43.6	1070	42.4
LL	325	46.9	1170	46.3	0.399
S allele	434	31.3	1642	32.5
L allele	952	68.7	3410	67.5	0.402
VNTR S <27, L ≥ 27 repeats
SS	93	13.4	370	14.6
SL	328	47.3	1157	45.8
LL	272	39.2	999	39.5	0.651
S allele	514	37.1	1897	37.5
L allele	872	62.9	3155	62.5	0.752
Haplotype 22-T
0	455	65.7	1631	64.6
1	209	30.2	774	30.6
2	29	4.2	121	4.8	0.752
other haplotypes	1119	80.7	4036	79.9
22 – T	267	19.3	1016	20.1	0.484
Haplotype 29 – A
0	185	26.7	718	28.4
1	356	51.4	1243	49.2
2	152	21.9	565	22.4	0.566
other haplotypes	726	52.4	2679	53.0
29 – A	660	47.6	2373	47.0	0.669

ISSN: 1471-2350