Table 2 T2D association for candidate SNPs in the Tunisian study sample of 1,397 individuals
Gene SNP | Genotype | Control/T2D | Additive model1 OR (95% CI) | P † | Dominant model2 OR (95% CI) | P ‡ | Recessive model3 OR (95% CI) | P* |
|---|---|---|---|---|---|---|---|---|
TCF7L2 rs7903146 | n | 511/863 | ||||||
CC (1/1) | 181/250 | |||||||
CT (1/2) | 235/396 | 1.24 (0.95–1.61) | 0.135 | |||||
TT (2/2) | 95/217 | 1.56 (1.13–2.16) | 0.002 | 1.33 (1.04–1.70) | 0.023 | 1.38 (1.04–1.83) | 0.025 | |
MAF (T) | 0.42/0.48 | 1.25 (1.06–1.47) | 0.006# | |||||
KCNJ11 rs5219 | n | 503/805 | ||||||
CC (1/1) | 250/371 | |||||||
CT (1/2) | 213/352 | 1.03 (0.80–1.31) | 0.399 | |||||
TT (2/2) | 40/82 | 1.23 (0.80–1.90) | 0.148 | 1.06 (0.84–1.34) | 0.630 | 1.22 (0.80–1.85) | 0.360 | |
MAF (T) | 0.29/0.32 | 1.07 (0.90–1.29) | 0.440# | |||||
GCKrs1799884 | n | 505/865 | ||||||
GG (1/1) | 324/552 | |||||||
GA (1/2) | 157/272 | 1.01 (0.79–1.30) | 0.939 | |||||
AA (2/2) | 24/41 | 1.20 (0.69–2.08) | 0.902 | 1.03 (0.81–1.32) | 0.780 | 1.20 (0.70–2.05) | 0.510 | |
MAF (A) | 0.20/0.20 | 1.04 (0.86–1.28) | 0.640# | |||||
HHEXrs7923837 | n | 504/795 | ||||||
GG (1/1) | 271/448 | |||||||
GA (1/2) | 200/292 | 0.88 (0.69–1.13) | 0.661 | |||||
AA (2/2) | 33/55 | 0.97 (0.60–1.58) | 0.934 | 0.89 (0.70–1.13) | 0.340 | 1.03 (0.64–1.65) | 0.910 | |
MAF (A) | 0.26/0.25 | 0.93 (0.77–1.13) | 0.470# | |||||
ENPP1 rs1044498 | n | 499/809 | ||||||
AA (1/1) | 228/402 | |||||||
AC (1/2) | 205/311 | 0.86 (0.67–1.12) | 0.243 | |||||
CC (2/2) | 66/96 | 0.78 (0.54–1.14) | 0.326 | 0.84 (0.66–1.07) | 0.160 | 0.84 (0.59–1.19) | 0.320 | |
MAF (C) | 0.33/0.31 | 0.88 (0.74–1.04) | 0.140# |