Genome screen in familial intracranial aneurysm

BMC Medical Genetics

Table 2 Sample demographics

	Narrower Disease Model	Broader Disease Model
Number of families	290	333
Number of genotyped individuals	1,647	1,895
% Caucasian, nonhispanic	84.5%	84.1%
Individuals meeting criteria for IA
Total Number	705	866
% Female	76	75
Average age at diagnosis (years)	49.2	49.7
% current (prior) smoker¹	47.9 (27.2)	48.4 (29.4)
Average pack years of smoking¹	28.6	29.8
% reporting hypertension¹	43.8	45.0
% reporting > 2 standard drinks per day¹	9.8	9.6
Individuals not meeting criteria for IA
Total Number	1025	1181
% Female	58	58
% current (prior) smoker²	28.6 (32.1)	27.3 (32.9)
Average pack years of smoking²	24.3	24.1
% reporting hypertension²	33.7	33.2
% reporting > 2 standard drinks per day²	8.9	9.1
# of all FIA family members undergoing MRA	318	380
% positive MRA (definite or probable)	2.8	7.6

¹ Data for the individuals with an IA is at the time of the identification of the aneurysm.
² Data for the individuals without an IA is at the time the questionnaire was completed.

ISSN: 1471-2350