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Table 2 Comparison of NOS2A htSNP allele frequencies between cases and controls and survival in cases

From: Nitric oxide synthase 2A (NOS2A) polymorphisms are not associated with invasive pneumococcal disease

Reference SNP Homozygou wild-type Presence of minor allele p-value 95% confidence interval for coefficient
  n (%) n (%) n (%) n (%)   
  Case-control
  Cases Controls Cases Controls   
rs8078340 172 (59) 485 (54) 122 (41) 412 (46) 0.078 -0.59, 0.03
rs2779248 260 (88) 797 (87) 37 (12) 121 (13) 0.431 -0.65, 0.28
rs16966563 203 (69) 634 (70) 90 (31) 270 (30) 0.714 -0.27, 0.39
rs3794763 193 (65) 575 (63) 102 (35) 337 (37) 0.331 -0.16, 0.48
rs1137933 183 (63) 580 (64) 109 (37) 326 (36) 0.908 -0.30, 0.34
rs17718148 212 (72) 677 (75) 81 (28) 229 (25) 0.718 -0.28, 0.40
rs4796052 201 (67) 673 (73) 97 (33) 240 (27) 0.106 -0.06, 0.59
rs2314809 158 (55) 485 (54) 131 (45) 415 (46) 0.956 -0.32, 0.30
rs2297512 157 (53) 496 (55) 138 (47) 407 (45) 0.913 -0.29, 0.32
  Survival (all IPD cases)
  Non-survivors Survivors Non-survivors Survivors   
rs8078340 33 (51) 139 (61) 32 (49) 90 (39) 0.675 -1.09, 0.70
rs2779248 57 (88) 203 (88) 8 (12) 29 (12) 0.936 -1.14, 1.24
rs16966563 41 (63) 162 (71) 24 (37) 66 (29) 0.935 -0.90, 0.98
rs3794763 39 (60) 154 (67) 26 (40) 76 (33) 0.101 -0.16, 1.75
rs1137933 36 (56) 147 (64) 28 (44) 81 (36) 0.592 -0.68, 1.19
rs17718148 40 (62) 172 (74) 25 (38) 59 (26) 0.811 -1.11, 0.86
rs4796052 40 (62) 161 (69) 25 (38) 72 (31) 0.194 -1.54, 0.31
rs2314809 37 (58) 121 (54) 27 (42) 104 (46) 0.684 -0.72, 1.10
rs2297512 37 (57) 121 (52) 28 (43) 110 (48) 0.558 -0.64, 1.19
  Survival (meningitis cases only)
  Non-survivors Survivors Non-survivors Survivors   
rs8078340 27 (47) 100 (62) 30 (53) 61 (38) 0.567 -1.20, 0.66
rs2779248 49 (86) 138 (85) 8 (14) 24 (15) 0.783 -1.37, 1.03
rs16966563 35 (61) 112 (70) 22 (39) 47 (30) 0.608 -0.93, 0.55
rs3794763 35 (61) 105 (65) 22 (39) 56 (35) 0.117 -0.20, 1.77
rs1137933 35 (63) 99 (62) 21 (37) 60 (38) 0.623 -0.72, 1.21
rs17718148 38 (67) 118 (73) 19 (33) 44 (27) 0.634 -1.25, 0.76
rs4796052 37 (65) 114 (70) 20 (35) 49 (30) 0.153 -1.66, 0.26
rs2314809 31 (55) 86 (54) 25 (45) 73 (46) 0.666 -0.75, 1.17
rs2297512 32 (56) 89 (55) 25 (44) 73 (45) 0.521 -0.64, 1.26
  1. Data adjusted for age and sex