A. Schematic view of the reporter gene construct driven by the endogenous -244/+1163 LXRB gene region. The black dot indicates rs17373080. B. Basal activities of the -244/+1163 rs17373080 G allele and C allele reporter constructs. Using in vitro mutagenesis with the G allele construct as a template a new C allele construct was generated. The results presented are mean differences of more than 20 independent transfection experiments. The activities of the G allele in each cell line analyzed were set to 100% ± SEM. * P < 0.05 by Student's t test.