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Figure 5 | BMC Medical Genetics

Figure 5

From: Prevalence of pathogenetic MC4R mutations in Italian children with early Onset obesity, tall stature and familial history of obesity

Figure 5

FACS Data. Fluorescence activated cell sorting analysis (FACS) of the MC4R Q307X mutation expressed in HEK-293. The total cell receptor expression levels were determined using permeabilized cells measuring both cell surface and intracellular protein expression. The cell surface expression levels were determined using non-permeabilized cells. Cell expression levels are presented relative to the wild type human-MC4R control. Total Q307X expression was 88%, surface expression was 31% and intracellular retention was about 57%.

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