|
Phenotype*
|
---|
Gene
|
BODE index
|
MRC score
|
6MWD, meters
|
Maximum workload, Watts
|
BMI, Kg/m2
|
FEV1, L
|
---|
IL6
|
0.38
|
0.41
|
0.48
|
0.81
|
0.66
|
0.22
|
CRP
|
0.33
|
0.41
|
0.11
|
0.06
|
0.56
|
0.70
|
FGB
|
0.74
|
0.61
|
0.61
|
0.64
|
0.44
|
0.72
|
- *Global association tests were adjusted for marker-specific clinical covariates selected by backward linear regression. Age and sex were included in all final models.
- Other covariates included in regression models per phenotype:
- BODE index: smoking status (former/current), PCO2 (kPa)
- MRC score: FEV1 (liters), smoking status (former/current)
- 6MWD: FEV1 (liters), Charlson co morbidity index, diastolic blood pressure, smoking status (former/current).
- Maximum workload: FEV1 (liters), Charlson co morbidity index, diastolic blood pressure, PCO2 (kPa), height.
- BMI: FEV1 (liters), smoking status (former/current), diastolic blood pressure, PCO2 (kPa)
- FEV1: Height, systolic and diastolic blood pressure, PCO2 (kPa) and PO2 (kPa).