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Table 7 COPD-related phenotypes and global association tests (P-values) for haplotypes of IL6, CRP and FGB

From: IL6 and CRPhaplotypes are associated with COPD risk and systemic inflammation: a case-control study

 

Phenotype*

Gene

BODE index

MRC score

6MWD, meters

Maximum workload, Watts

BMI, Kg/m2

FEV1, L

IL6

0.38

0.41

0.48

0.81

0.66

0.22

CRP

0.33

0.41

0.11

0.06

0.56

0.70

FGB

0.74

0.61

0.61

0.64

0.44

0.72

  1. *Global association tests were adjusted for marker-specific clinical covariates selected by backward linear regression. Age and sex were included in all final models.
  2. Other covariates included in regression models per phenotype:
  3. BODE index: smoking status (former/current), PCO2 (kPa)
  4. MRC score: FEV1 (liters), smoking status (former/current)
  5. 6MWD: FEV1 (liters), Charlson co morbidity index, diastolic blood pressure, smoking status (former/current).
  6. Maximum workload: FEV1 (liters), Charlson co morbidity index, diastolic blood pressure, PCO2 (kPa), height.
  7. BMI: FEV1 (liters), smoking status (former/current), diastolic blood pressure, PCO2 (kPa)
  8. FEV1: Height, systolic and diastolic blood pressure, PCO2 (kPa) and PO2 (kPa).