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Table 7 COPD-related phenotypes and global association tests (P-values) for haplotypes of IL6, CRP and FGB

From: IL6 and CRPhaplotypes are associated with COPD risk and systemic inflammation: a case-control study

  Phenotype*
Gene BODE index MRC score 6MWD, meters Maximum workload, Watts BMI, Kg/m2 FEV1, L
IL6 0.38 0.41 0.48 0.81 0.66 0.22
CRP 0.33 0.41 0.11 0.06 0.56 0.70
FGB 0.74 0.61 0.61 0.64 0.44 0.72
  1. *Global association tests were adjusted for marker-specific clinical covariates selected by backward linear regression. Age and sex were included in all final models.
  2. Other covariates included in regression models per phenotype:
  3. BODE index: smoking status (former/current), PCO2 (kPa)
  4. MRC score: FEV1 (liters), smoking status (former/current)
  5. 6MWD: FEV1 (liters), Charlson co morbidity index, diastolic blood pressure, smoking status (former/current).
  6. Maximum workload: FEV1 (liters), Charlson co morbidity index, diastolic blood pressure, PCO2 (kPa), height.
  7. BMI: FEV1 (liters), smoking status (former/current), diastolic blood pressure, PCO2 (kPa)
  8. FEV1: Height, systolic and diastolic blood pressure, PCO2 (kPa) and PO2 (kPa).
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BMC Medical Genetics

ISSN: 1471-2350

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