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Table 4 Frequency distribution in patients and controls and global association tests for haplotypes of IL6, CRP and FGB

From: IL6 and CRPhaplotypes are associated with COPD risk and systemic inflammation: a case-control study

Gene Haplotype* Controls
%
COPD
%
Global test P-values†
     COPD Ln
(IL-6)
Ln
(CRP)
Ln
(fibrinogen)
IL6 H1 1111111 17.8 16.1 0.003 0.80 0.08 0.73
  H2 1111112 2.4 6.2     
  H3 1112111 4.8 10.2     
  H4 1112112 27.8 25.0     
  H5 2121211 20.1 16.1     
  H6 2121221 10.4 7.7     
  H7 2221211 10.1 6.3     
CRP H1 111121 28.7 26.6 0.09 Not tested 0.0004 Not tested
  H2 111211 30.3 24.2     
  H3 121211 4.9 8.2     
  H4 212111 29.7 30.4     
  H5 311112 5.4 7.3     
FGB H1 1111 11.9 10.3 0.28 Not tested Not tested 0.72
  H2 1112 31.2 32.8     
  H3 1121 21.0 19.2     
  H4 1211 18.2 20.9     
  H5 2111 17.4 16.2     
  1. * 1 codes the common allele and 2 codes the minor allele. IL6 loci are presented in the order rs2069825, rs2069827, rs1800797, rs2069840, rs1554606, rs2069861 and rs1818879. CRP loci are presented in the order rs3091244, rs1800947, rs1130864, rs1205, rs2808630 and rs3090077. FGB loci are presented in the order rs1800791, rs1800788, rs1800787 and rs2227421
  2. † Global test p-value from haplo.score for overall association between haplotypes and trait. The COPD analysis was adjusted for age, sex and tobacco consumption (pack-years smoked). Inflammatory markers levels analyses were adjusted for marker-specific clinical covariates: age, sex and 6MWD (all genes) and BMI (only for CRP).