Skip to main content

Table 4 Frequency distribution in patients and controls and global association tests for haplotypes of IL6, CRP and FGB

From: IL6 and CRPhaplotypes are associated with COPD risk and systemic inflammation: a case-control study

Gene

Haplotype*

Controls

%

COPD

%

Global test P-values†

    

COPD

Ln

(IL-6)

Ln

(CRP)

Ln

(fibrinogen)

IL6

H1 1111111

17.8

16.1

0.003

0.80

0.08

0.73

 

H2 1111112

2.4

6.2

    
 

H3 1112111

4.8

10.2

    
 

H4 1112112

27.8

25.0

    
 

H5 2121211

20.1

16.1

    
 

H6 2121221

10.4

7.7

    
 

H7 2221211

10.1

6.3

    

CRP

H1 111121

28.7

26.6

0.09

Not tested

0.0004

Not tested

 

H2 111211

30.3

24.2

    
 

H3 121211

4.9

8.2

    
 

H4 212111

29.7

30.4

    
 

H5 311112

5.4

7.3

    

FGB

H1 1111

11.9

10.3

0.28

Not tested

Not tested

0.72

 

H2 1112

31.2

32.8

    
 

H3 1121

21.0

19.2

    
 

H4 1211

18.2

20.9

    
 

H5 2111

17.4

16.2

    
  1. * 1 codes the common allele and 2 codes the minor allele. IL6 loci are presented in the order rs2069825, rs2069827, rs1800797, rs2069840, rs1554606, rs2069861 and rs1818879. CRP loci are presented in the order rs3091244, rs1800947, rs1130864, rs1205, rs2808630 and rs3090077. FGB loci are presented in the order rs1800791, rs1800788, rs1800787 and rs2227421
  2. † Global test p-value from haplo.score for overall association between haplotypes and trait. The COPD analysis was adjusted for age, sex and tobacco consumption (pack-years smoked). Inflammatory markers levels analyses were adjusted for marker-specific clinical covariates: age, sex and 6MWD (all genes) and BMI (only for CRP).