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Table 3 Tagging SNPs characteristics and single SNP association analysis for COPD

From: IL6 and CRPhaplotypes are associated with COPD risk and systemic inflammation: a case-control study

dbSNP No. tagSNP* Gene region Minor allele frequency P-value alleles† OR adj‡ genotypes
(95%CI)
P-value genotypes
    Controls COPD    
IL6 gene (7p21-p15)
rs2069825 205CT/- 5'flanking 0.42 0.37 0.11 0.87
(0.64–1.17)
0.35
rs2069827 321G/T 5'flanking 0.10 0.07 0.10 0.67
(0.39–1.14)
0.14
rs1800797 1086G/A 5'flanking 0.44 0.39 0.12 0.86
(0.64–1.16)
0.32
rs2069840 3437C/G intron 0.34 0.36 0.52 1.04
(0.76–1.42)
0.81
rs1554606 3572G/T intron 0.46 0.42 0.19 0.84
(0.62–1.13)
0.25
rs2069849 6021C/T synonymous 0.03 0.02 0.33 0.51
(0.19–1.36)
0.18
rs2069861 6519C/T 3'flanking 0.11 0.09 0.24 0.93
(0.57–1.52)
0.77
rs1818879 7592G/A 3'flanking 0.32 0.39 0.02 1.49
(1.08–2.04)
0.01
CRP gene (1q21-q23)
rs3091244 1440C/T 5'flanking 0.30 0.31 0.08 1.01
(0.73–1.40)
0.94
  1440C/A   0.06 0.08   1.57
(0.88–2.79)
0.12
rs1800947 2667G/C synonymous 0.05 0.08 0.03 1.80
(0.96–3.37)
0.06
rs1130864 3014C/T 3' UTR 0.30 0.31 0.65 1.05
(0.76–1.46)
0.76
rs1205 3872G/A 3'-flanking 0.35 0.33 0.41 0.98
(0.73–1.32)
0.91
rs2808630 5237A/G 3'-flanking 0.29 0.27 0.55 0.83
(0.60–1.15)
0.27
rs3090077 6469A/C 3'-flanking 0.05 0.08 0.15 1.59
(0.86–2.96)
0.14
FGB gene (4q28)
rs1800791 1038G/A 5' flanking 0.18 0.17 0.63 0.80
(0.55–1.18)
0.26
rs1800788 1643C/T 5' flanking 0.18 0.21 0.31 1.36
(0.94–1.95)
0.10
rs1800787 1744C/T 5' flanking 0.21 0.20 0.59 1.10
(0.75–1.61)
0.62
rs2227421 9952A/C 3' UTR 0.31 0.33 0.59 1.03
(0.74–1.42)
0.87
  1. * TagSNPs are numbered by position in sequences AF449713 for CRP, AF372214 for IL6 and AF388026 for FGB. Base change common allele/rare allele.
  2. † P value is for the test of allele counting in cases versus controls.
  3. ‡ Logistic regression analysis was adjusted for age, sex and tobacco consumption (pack-years smoked)