Table 1 Baseline characteristics of COPD patients and healthy controls*
From: IL6 and CRPhaplotypes are associated with COPD risk and systemic inflammation: a case-control study
Characteristics | Controls N = 195 | COPD N = 355 | P-value |
|---|---|---|---|
Years of age | 54.3 (7.3) | 64.2 (9.4) | <0.001 |
Male, N (%) | 94 (48) | 219 (62) | 0.002 |
Current smoker, N (%) | 115 (59%) | 90 (25%) | <0.001 |
Tobacco consumption, pack years-smoked | 29.6 (14.8) | 39.9 (18.5) | <0.001 |
FEV1, liters | 3.2 (0.7) | 1.1 (0.5) | <0.001 |
FEV1,%pred | 103.3 (15.1) | 41.9 (16.0) | <0.001 |
FEV1/FVC, % | 78.3 (5.3) | 42.0 (11.9) | <0.001 |
FVC, liters | 4.1 (0.9) | 3.0 (0.9) | <0.001 |
FVC,%pred | 109.3 (16.8) | 86.3 (21.1) | <0.001 |
BMI, kg/m2 | 26.4 (3.7) | 25.0 (5.0) | <0.001 |
Hypertension†, N (%) | 33 (17%) | 88 (25%) | 0.01 |
PaO2, kPa | - | 9.2 (1.37) | |
PaCO2, kPa | - | 5.5 (0.80) | |
Long-term oxygen therapy, N (%) | - | 82 (23.43) | |
6 minute walking distance, meters | - | 420.1 (127.9) | |
Maximum workload, watts | - | 72.6 (33.9) | |
Maximum workload,% pred | - | 56.6 (25.2) | |
MRC dyspnea score | - | 3 (2–4) | |
BODE index | 4.3 (2.1) | ||
Systolic blood pressure, mm/Hg | - | 135.9 (23.31) | |
Diastolic blood pressure, mm/Hg | - | 81.1 (13.09) | |
Charlson co morbidity index‡ | - | 1 (1–8) | |
CRP, mg/L | 1.3 (0.2–3.19) | 4.6 (1.3–11.09) | <0.001 |
IL-6, pg/mL | 0.7 (0.45–1.38) | 2.1 (1.15–4.24) | <0.001 |
Fibrinogen, g/L | 3.3 (3.00–3.60) | 3.6 (3.23–3.82) | <0.001 |
Number of plasma markers in the top quartile: | <0.001 | ||
0, N (%) | 155 (79.4%) | 159 (44.5%) | |
1, N (%) | 29 (14.4%) | 88 (24.2%) | |
2–3, N (%) | 10 (5.2%) | 118 (31.3%) | |
CRP < 1 mg/L | 93 (47.9%) | 68 (19.2%) | <0.001 |
CRP 1–3 mg/L | 51 (26.3%) | 81 (22.8%) | |
CRP 3–10 mg/L | 40 (20.6%) | 109 (30.7%) | |
CRP > 10 mg/L | 10 (5.2%) | 97 (27.3%) |