Serum soluble IL-2RA in SLE and AAV and its relationship with disease activity and genotype at rs11594656. (a) A comparison of SLE and AAV soluble IL-2RA (sIL-2RA) at time 0 and 3 months compared with controls, as assessed by ELISA. Each dot represents a patient. (b, c) Correlation between disease activity and sIL-2RA. (BILAG for SLE; BVAS for AAV; see supplementary information). r2 and P values from linear regression modelling are shown. (d, e) sIL-2RA levels stratified by genotype at rs11594656 at both time 0 and 3 months for SLE (d) and AAV (e). P values for panels (a), (d) & (e) were generated using the Mann-Whitney test.