Figure 1

SLE and AAV are associated with different SNPs in the IL2RA region. The genomic context of rs2104286, rs41295061 and rs11594656 is shown, using the GBrowse implementation in T1DBase http://www.t1dbase.org. All are non-coding SNPs. Negative decimal logarithms of P values (χ² test; 1 degree of freedom) from each cohort from SLE and AAV are plotted for rs41295061 and rs11594656 but not for rs2104286, as an association of this MS-associated SNP was not detected with SLE or AAV (table 1). Open circles represent the KRUK case-control cohort; filled circles the Imperial case-control cohort and open squares the Imperial family trios (P value from TDT). The filled square represents the combined P value for rs11594656 in SLE. Crosses are used for the AAV cohort. The dashed lines correspond to P = 0.05.