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Table 2 Case-control studies of overweight, obesity and morbid obesity in the combined study sample

From: Studies of CTNNBL1 and FDFT1variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes

CTNNBL1rs6013029 n
(men/women) 		Genotype distribution
nGG/GT/TT (%) 		MAF
(95% CI) 		p add p dom ORadd
(95% CI)
Controls 5,190 (2,271/3,019) 4,740/444/6
(91.4/8.5/0.1) 		4.4
(4.0–4.8) 		   
Overweight cases 7,229 (4,496/2,733) 6,589/629//11
(91.1/8.7/0.2) 		4.5
(4.2–4.9) 		0.7 0.8 1.02
(0.90–1.16)
Obese cases 4,928 (2,543/2,385) 4,464/456/8
(90.5/9.3/0.2) 		4.8
(4.4–5.2) 		0.2 0.2 1.09
(0.95–1.25)
Morbid obese cases 399
(135/264) 		356/43/0
(89.1/10.9/0.0) 		5.4
(3.9–7.2) 		0.2 0.1 1.26
(0.91–1.74)
CTNNBL1 rs6020846 n
(men/women) 		Genotype distribution
n AA/GA/GG (%) 		MAF
(95% CI) 		p add p dom OR add
(95% CI)
Controls 5,188 (2,169/3,019) 4,673/504/11
(90.1/9.7/0.2) 		5.1
(4.7–5.5) 		   
Overweight cases 7,204 (4,492/2,712) 6,448/738/18
(89.4/10.3/0.2) 		5.4
(5.0–5.8) 		0.5 0.5 1.05
(0.93–1.18)
Obese cases 4,905 (2,533/2,372) 4,358/531/16
(88.8/10.9/0.3) 		5.7
(5.3–6.2) 		0.06 0.06 1.13
(1.00–1.28)
Morbid obese cases 394
(134/260) 		348/46/0
(88.2/11.8/0.0) 		5.8
(4.3–7.7) 		0.3 0.2 1.17
(0.86–1.61)
FDFT1 rs7001819 n
(men/women) 		Genotype distribution
n TT/TC/CC (%) 		MAF
(95% CI) 		p add p dom OR add
(95% CI)
Controls 5,089
(2,123/2,966) 		2,084/2,367/638
(40.9/46.5/12.6) 		35.8
(34.9–36.7) 		   
Overweight cases 7,078
(4,391/2,687) 		2,843/3,281/954
(40.2/46.3/13.5) 		36.7
(35.9–37.5) 		0.5 0.6 1.02
(0.97–1.08)
Obese cases 4,810
(2,491/2,319) 		1,963/2,258/589
(40.6/47.1/12.3) 		35.7
(34.8–36.7) 		0.6 0.9 0.99
(0.93–1.05)
Morbid obese cases 387
(131/256) 		158/184/45
(41.0/47.5/11.5) 		35.4
(32.0–38.9) 		0.9 0.9 0.99
(0.85–1.16)
  1. Data are number of subjects, divided into genotype groups (% in each group), frequencies of the minor allele (MAF) in percentages (95% CI) and odds ratio (OR) for an additive (add) model (95% CI). Since the CTNNBL1 variants are rather rare, the p-values are given for both an additive and dominant (dom) model. Differences in genotype distribution were evaluated using logistic regression. p-values were adjusted for age and sex. Controls were defined as BMI < 25 kg/m2, overweight cases as 25 kg/m2 ≤ BMI < 30 kg/m2, obese cases as BMI ≥ 30 kg/m2 and morbid obese cases as BMI ≥ 40 kg/m2.
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BMC Medical Genetics

ISSN: 1471-2350

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