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Table 2 Case-control studies of overweight, obesity and morbid obesity in the combined study sample

From: Studies of CTNNBL1 and FDFT1variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes

CTNNBL1rs6013029

n

(men/women)

Genotype distribution

nGG/GT/TT (%)

MAF

(95% CI)

p add

p dom

ORadd

(95% CI)

Controls

5,190 (2,271/3,019)

4,740/444/6

(91.4/8.5/0.1)

4.4

(4.0–4.8)

   

Overweight cases

7,229 (4,496/2,733)

6,589/629//11

(91.1/8.7/0.2)

4.5

(4.2–4.9)

0.7

0.8

1.02

(0.90–1.16)

Obese cases

4,928 (2,543/2,385)

4,464/456/8

(90.5/9.3/0.2)

4.8

(4.4–5.2)

0.2

0.2

1.09

(0.95–1.25)

Morbid obese cases

399

(135/264)

356/43/0

(89.1/10.9/0.0)

5.4

(3.9–7.2)

0.2

0.1

1.26

(0.91–1.74)

CTNNBL1 rs6020846

n

(men/women)

Genotype distribution

n AA/GA/GG (%)

MAF

(95% CI)

p add

p dom

OR add

(95% CI)

Controls

5,188 (2,169/3,019)

4,673/504/11

(90.1/9.7/0.2)

5.1

(4.7–5.5)

   

Overweight cases

7,204 (4,492/2,712)

6,448/738/18

(89.4/10.3/0.2)

5.4

(5.0–5.8)

0.5

0.5

1.05

(0.93–1.18)

Obese cases

4,905 (2,533/2,372)

4,358/531/16

(88.8/10.9/0.3)

5.7

(5.3–6.2)

0.06

0.06

1.13

(1.00–1.28)

Morbid obese cases

394

(134/260)

348/46/0

(88.2/11.8/0.0)

5.8

(4.3–7.7)

0.3

0.2

1.17

(0.86–1.61)

FDFT1 rs7001819

n

(men/women)

Genotype distribution

n TT/TC/CC (%)

MAF

(95% CI)

p add

p dom

OR add

(95% CI)

Controls

5,089

(2,123/2,966)

2,084/2,367/638

(40.9/46.5/12.6)

35.8

(34.9–36.7)

   

Overweight cases

7,078

(4,391/2,687)

2,843/3,281/954

(40.2/46.3/13.5)

36.7

(35.9–37.5)

0.5

0.6

1.02

(0.97–1.08)

Obese cases

4,810

(2,491/2,319)

1,963/2,258/589

(40.6/47.1/12.3)

35.7

(34.8–36.7)

0.6

0.9

0.99

(0.93–1.05)

Morbid obese cases

387

(131/256)

158/184/45

(41.0/47.5/11.5)

35.4

(32.0–38.9)

0.9

0.9

0.99

(0.85–1.16)

  1. Data are number of subjects, divided into genotype groups (% in each group), frequencies of the minor allele (MAF) in percentages (95% CI) and odds ratio (OR) for an additive (add) model (95% CI). Since the CTNNBL1 variants are rather rare, the p-values are given for both an additive and dominant (dom) model. Differences in genotype distribution were evaluated using logistic regression. p-values were adjusted for age and sex. Controls were defined as BMI < 25 kg/m2, overweight cases as 25 kg/m2 ≤ BMI < 30 kg/m2, obese cases as BMI ≥ 30 kg/m2 and morbid obese cases as BMI ≥ 40 kg/m2.
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