Skip to main content

Table 2 Results of hierarchical logistic regression analysis aimed at determining whether the TP53 codon 72 and DRD4 uVNTR polymorphisms were associated with schizophrenia after the contributions of age and gender were taken into account.

From: Association of DRD4 uVNTR and TP53 codon 72 polymorphisms with schizophrenia: a case-control study

Model 1.

      

Variables

B

S.E.

Wald

df

Sig.

Exp(B)

Gender

--0.891

0.128

48.735

1

< 0.001**

0.410

Age

--0.045

0.005

83.772

1

< 0.001**

0.956

P53CC

0.218

0.171

1.618

1

0.203

1.244

P53GG

0.083

0.146

0.320

1

0.571

1.086

Constant

3.760

0.276

185.052

1

< 0.001

42.954

Model 2.

      

Variables

B

S.E.

Wald

df

Sig.

Exp(B)

Gender

--0.891

0.128

48.735

1

< 0.001**

0.410

Age

--0.045

0.005

83.772

1

< 0.001**

0.956

DRD4c

0.841

0.401

4.393

1

0.036*

2.319

Constant

3.777

0.270

195.381

1

< 0.001

43.668

Model 3.

      

Variables

B

S.E.

Wald

df

Sig.

Exp(B)

Gender

--0.891

0.128

48.735

1

< 0.001**

0.410

Age

--0.045

0.005

83.772

1

< 0.001**

0.956

DRD4c by p53CC

1.459

1.054

1.916

1

0.166

4.302

Constant

3.819

0.270

200.781

1

< 0.001

45.573

  1. B: coefficient of regression; S.E.: Standard Error; Wald: the index of regression effect; df: degrees of freedom; Sig: P value; Exp(B): odds ratio; p53CC: dummy variable where 1 refers to the CC genotype of the TP53 codon 72 polymorphism and 0 refers to the other possible genotypes; p53GG: dummy variable where 1 refers to the GG genotype of the TP53 codon 72 polymorphism and 0 refers to the other possible genotypes; DRD4c: dummy variable where 1 refers to the long form allelic variants of the DRD4 uVNTR polymorphism (≥ 5 repeats) and 0 refers to the short form allelic variants (≤ 4 repeats); DRD4c by p53CC: the genetic effect attributed to the possible interaction between the long form variants of the DRD4 uVNTR polymorphism and the CC genotype of the TP53 codon 72 polymorphism; ** indicates statistical significance (p < 0.001).