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Table 1 The distributions of genotypes and alleles for the TP53 codon 72 and DRD4 uVNTR polymorphisms.

From: Association of DRD4 uVNTR and TP53 codon 72 polymorphisms with schizophrenia: a case-control study

Polymorphism

Genotype frequency (%)

HWE-p

p value

Allele frequency (%)

P value

Odds ratio (95% CI)

rs8064946

C/C

C/G

G/G

  

C (Pro72)

G (Arg72)

  

Patient (n = 917)

193 (21.05)

453 (49.40)

271(29.55)

0.884

0.229

839 (45.75)

995 (54.25)

0.404

1.072 (0.910--1.262)a

Control (n = 427)

74 (17.33)

228 (53.40)

125 (29.27)

0.084

 

376 (44.03)

478 (55.97)

  

DRD4 uVNTR

2/2

2/3

2/4

2/5

3/3

3/4

3/5

4/4

4/5

4/6

5/6

  

Short (≤ 4 repeats)

Long (≥ 5 repeats)

  

Patient (n = 914)

60

0

263

8

1

16

1

521

24

19

1

 

< 0.001

1774 (97.05)

54 (2.95)

0.001

3.189 1.535--6.622)b

Control (n = 423)

49

1

78

3

1

6

0

280

2

3

0

  

838 (99.05)

8 (0.95)

  
  1. Genotyping results for the TP53 codon 72 polymorphism were lacking for 17 patients with schizophrenia and six controls; genotyping information for the DRD4 uVNTR polymorphism was lacking for 20 patients with schizophrenia and 10 controls; HWE-p: p value of chi-square test for Hardy--Weinberg Equilibrium; a: odds ratio of the C allele to the G allele of the codon 72 polymorphism in TP53in relation to schizophrenia; b: odds ratio of the long form variants (≥ 5 repeats) to the short form variants (≤ 4 repeats) shows the former confers enhanced risk of vulnerability to schizophrenia.