Table 2 PRNP gene sequence variation in sCJD cases and controls
PRNPVariation | 309 sCJD Patients | 192 UK DNA Controls | 778 Scottish Blood Donor Controls |
|---|---|---|---|
Codon 129 (Met/Val) | MM (n = 184; 59.5%) MV (n = 66; 21.4%) VV (n = 59; 19.1%) | MM (n = 90; 46.9%) MV (n = 87; 45.3%) VV (n = 15; 7.8%) | MM (n = 337; 43.3%) MV (n = 344; 44.2%) VV (n = 97; 12.5%) |
Codon 117 (Ala/Ala) | n = 13; 4.2% (10.4% of MV/VV cases) | n = 9; 4.7% (10.3% of MV/VV cases) | n = 47; 6.0% (10.7% of MV/VV cases) |
24 bp Deletion | n = 4; 1.3% Deletion Class R34 (n = 3) R3 (n = 1) | n = 1; 0.5% Deletion Class R2 (n = 1) | n = 12; 1.5% Deletion Class R34 (n = 12) |
Codon 167 (Asp/Gly) | DG (n = 1; 0.32%) | (no sequence data available) | (no sequence data available) |
Codon 68 (Pro/Pro) | PP (n = 1; 0.32%) | (no sequence data available) | (no sequence data available) |