Table 2 Results of the best SNPs in SH3PXD2B, SLIT3 and FLJ42133 as previously described [6] in two independent GWAs.
Case-control1 | KORA cohort2 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | SNP | Alleles3 | MAF4 cases/controls | Genotype distribution cases (%)/controls (%) | Odds ratio (95% CI) | Two-sided p-value | One-sided p-value | MAF | β (95% CI) | Two-sided p-value | One-sided p-value | ||
SH3PXD2B | rs13356223 | T/C | 0.033/ 0.032 | 454 (93.4)/ 410 (93.8) | 32(6.6)/ 26 (6.0) | 0/ 1 (0.2) | 1.029 (0.614 – 1.722) | 0.915 | 0.457 | 0.041 | -0.549 (-1.235 – 0.136) | 0.116 | 0.942 |
rs10077897 | G/A | 0.040/ 0.036 | 447 (92.0)/ 411 (93.0) | 39 (8.0)/ 30 (6.8) | 0/ 1 (0.2) | 1.114 (0.690 – 1.799) | 0.658 | 0.329 | 0.046 | -0.430 (-1.086 – 0.225) | 0.198 | 0.901 | |
rs13436547 | G/A | 0.033/ 0.032 | 455 (93.4)/ 415 (93.9) | 32 (6.6)/ 26 (5.9) | 0/ 1 (0.2) | 1.038 (0.620 – 1.739) | 0.886 | 0.443 | 0.041 | -0.486 (-1.172 – 0.201) | 0.165 | 0.917 | |
SLIT3 | rs17734503 | A/G | 0.082/ 0.072 | 409 (84.0)/ 380 (86.0) | 76 (15.6)/ 60 (13.6) | 2 (0.4)/ 2 (0.4) | 1.150 (0.814 – 1.626) | 0.428 | 0.214 | 0.086 | 0.358 (-0.109 – 0.825) | 0.133 | 0.066 |
rs12654448 | C/T | 0.079/ 0.071 | 410 (84.4)/ 381 (86.2) | 75 (15.4)/ 59 (13.3) | 1 (0.2)/ 2 (0.5) | 1.126 (0.791 – 1.602) | 0.510 | 0.255 | 0.088 | 0.125 (-0.352 – 0.601) | 0.608 | 0.304 | |
FLJ42133 | rs7363432 | A/G | 0.066/ 0.070 | 424 (87.1)/ 383 (86.6) | 62 (12.7)/ 56/(12.7) | 1 (0.2)/ 3 (0.7) | 0.932 (0.649 – 1.340) | 0.704 | 0.648 | 0.057 | 0.234 (-0.369 – 0.837) | 0.447 | 0.223 |
rs6095722 | A/G | 0.066/ 0.070 | 422 (87.0)/ 383 (86.6) | 62 (12.8)/ 56/(12.7) | 1 (0.2)/ 3 (0.7) | 0.936 (0.651 – 1.346) | 0.722 | 0.639 | 0.060 | 0.134 (-0.447 – 0.715) | 0.651 | 0.325 | |