Table 1 Results of the best SNPs in CTNNBL1 as previously described [6] in two independent GWAs.
Case-control1 | KORA cohort2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | Alleles4 | MAF5 cases/controls | Genotype distribution cases (%)/controls (%) | Odds ratio (95% CI) | Two-sided p-value | One-sided p-value | MAF | β (95% CI) | Two-sided p-value | One-sided p-value | ||
rs6013029 3 | G/T | 0.057/ 0.064 | 432(88.7)/ 387(87.6) | 54(11.1)/ 53(12.0) | 1(0.2)/ 2(0.4) | 0.884 (0.603 – 1.296) | 0.528 | 0.736 | 0.051 | 0.1013 (-0.522 – 0.724) | 0.750 | 0.375 |
rs16986921 | C/T | 0.056/ 0.062 | 433(88.9)/ 388(88.0) | 53(10.9)/ 51(11.6) | 1(0.2)/ 2(0.4) | 0.899 (0.611 – 1.324) | 0.591 | 0.705 | 0.052 | 0.1585 (-0.463 – 0.780) | 0.617 | 0.309 |
rs6020712 | G/A | 0.056/ 0.064 | 433(88.9)/ 387(87.6) | 53(10.9)/ 53(12.0) | 1(0.2)/ 2(0.4) | 0.867 (0.591 – 1.273) | 0.467 | 0.766 | 0.052 | 0.1052 (-0.515 – 0.725) | 0.740 | 0.370 |
rs6020846 | A/G | 0.066/ 0.070 | 424(87.1)/ 383(86.7) | 62(12.7)/ 56(12.7) | 1(0.2)/ 3(0.7) | 0.932126 (0.649 – 1.340) | 0.704 | 0.648 | 0.060 | 0.0531 (-0.529 – 0.635) | 0.858 | 0.429 |
rs6020395 | G/C | 0.070/ 0.075 | 418(86.2)/ 376(85.6) | 66(13.6)/ 60(13.7) | 1(0.2)/ 3(0.7) | 0.927 (0.650 – 1.320) | 0.673 | 0.664 | 0.064 | 0.1279 (-0.444 – 0.700) | 0.661 | 0.331 |
rs16986890 | A/G | NA6 | 0.061 | -0.1227 (-0.682 – 0.436) | 0.667 | 0.666 | ||||||
rs6096781 | T/C | 0.063/ 0.055 | 427(87.7)/ 396(89.6) | 59(12.1)/ 43(9.7) | 1(0.2)/ 3(0.7) | 1.136 (0.773 – 1.670) | 0.515 | 0.257 | 0.053 | 0.0956 (-0.517 – 0.708) | 0.760 | 0.380 |
rs6020339 | T/C | 0.372/ 0.070 | 197(40.5)/ 383 (86.6) | 216(44.4)/ 56/(12.7) | 73(15.0)/ 3 (0.7) | 0.962 (0.651 – 1.346) | 0.678 | 0.661 | 0.380 | -0.0032 (-0.447 – 0.715) | 0.982 | 0.509 |