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Table 8 Proportions of cases and controls with different SNP-genotypes at the CSF2 locus and risk estimates from conditional logistic regression (CLR) analysis of matched 307 case-control pairs for each SNP for trichiasis

From: Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians

   

Multiplicative model

Dominant model

Recessive model

Genotype

# of genotypes (freq)

CLR

OR (95%CI)

OR (95%CI)

 

TT cases

controls

OR (95%CI)

P value

P value

P value

GM-CSF2_27348 TT

198(0.69)

179(0.59)

Reference

-

0.62(0.42,0.90)

0.42 (0.18,0.98)

GM-CSF2_27348 TA

82 (0.28)

103(0.34)

0.67(0.45,0.99)

0.048

0.012

0.046

GM-CSF2_27348 AA

9 (0.03)

20 (0.07)

0.37(0.16,0.87)

0.024

  

Test for trend

  

0.64(0.47,0.88)

0.005

  

GM-CSF2_2069614CC

108(0.36)

94 (0.31)

Reference

-

0.77(0.57,1.12)

0.82 (0.53,1.26)

GM-CSF2_2069614 CT

138(0.46)

146(0.48)

0.79(0.53,1.18)

0.254

0.171

0.359

GM-CSF2_2069614 TT

54 (0.18)

65 (0.21)

0.70(0.42,1.16)

0.172

  

Test for trend

  

0.83(0.65,1.07)

0.154

  

GM-CSF2_27438 AA

101(0.33)

127(0.40)

Reference

-

1.29(0.91,1.83)

1.14 (0.74,1.75)

GM-CSF2_27438 AG

145(0.48)

132(0.42)

1.28(0.88,1.85)

0.195

0.157

0.56

GM-CSF2_27438 GG

57 (0.19)

55(0.18)

1.31(0.81,2.13)

0.268

  

Test for trend

  

1.17(0.92,1.48)

0.203

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