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Table 8 Proportions of cases and controls with different SNP-genotypes at the CSF2 locus and risk estimates from conditional logistic regression (CLR) analysis of matched 307 case-control pairs for each SNP for trichiasis

From: Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians

    Multiplicative model Dominant model Recessive model
Genotype # of genotypes (freq) CLR OR (95%CI) OR (95%CI)
  TT cases controls OR (95%CI) P value P value P value
GM-CSF2_27348 TT 198(0.69) 179(0.59) Reference - 0.62(0.42,0.90) 0.42 (0.18,0.98)
GM-CSF2_27348 TA 82 (0.28) 103(0.34) 0.67(0.45,0.99) 0.048 0.012 0.046
GM-CSF2_27348 AA 9 (0.03) 20 (0.07) 0.37(0.16,0.87) 0.024   
Test for trend    0.64(0.47,0.88) 0.005   
GM-CSF2_2069614CC 108(0.36) 94 (0.31) Reference - 0.77(0.57,1.12) 0.82 (0.53,1.26)
GM-CSF2_2069614 CT 138(0.46) 146(0.48) 0.79(0.53,1.18) 0.254 0.171 0.359
GM-CSF2_2069614 TT 54 (0.18) 65 (0.21) 0.70(0.42,1.16) 0.172   
Test for trend    0.83(0.65,1.07) 0.154   
GM-CSF2_27438 AA 101(0.33) 127(0.40) Reference - 1.29(0.91,1.83) 1.14 (0.74,1.75)
GM-CSF2_27438 AG 145(0.48) 132(0.42) 1.28(0.88,1.85) 0.195 0.157 0.56
GM-CSF2_27438 GG 57 (0.19) 55(0.18) 1.31(0.81,2.13) 0.268   
Test for trend    1.17(0.92,1.48) 0.203