Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population

Table 3 Allele frequency distribution of HLA-DRB1* in early versus late-onset leprosy groups

Alleles	Controls	Early onset			Late-onset
	(n = 527)	(n = 141)			(n = 164)
	AF	AF	P -value	Pc -value	AF	P -value	Pc -value
HLA-DRB101*	0.02	0.03	0.924		0.04	0.162
HLA-DRB103*	0.04	0.03	0.848		0.02	0.320
HLA-DRB104*	0.09	0.09	0.685		0.06	0.406
HLA-DRB107*	0.16	0.10	0.130		0.14	0.848
HLA-DRB108*	0.05	0.05	0.926		0.05	0.723
**HLA-DRB109***	0.13	0.06	0.003	0.039	0.10	0.256
HLA-DRB110*	0.01	0.003	0.168		0.01	0.285
HLA-DRB111*	0.07	0.07	0.688		0.07	0.503
HLA-DRB112*	0.11	0.11	0.480		0.09	0.324
**HLA-DRB113***	0.06	0.04	0.017	0.221	0.05	0.429
HLA-DRB114*	0.05	0.05	0.607		0.05	0.988
**HLA-DRB115***	0.18	0.35	< 0.001	< 0.001	0.29	< 0.001	< 0.001
HLA-DRB116*	0.03	0.03	0.758		0.02	0.495

ISSN: 1471-2350