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Table 3 Summary of the SNPs significantly associated with atopy at an individual level

From: A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS)

     

ECHRS Atopy vs. controls

SNP

Gene

MAF

Chromosome

Position (build36)

Pooling

Replication

Combined

rs11124858*

SGK493

0.367

2

42113828

0.0021

0.0318

0.0007†

rs13409978*

SGK493

0.122

2

42119206

0.0007†

0.0124

0.0001†

rs4952590**

SGK493

0.141

2

42130425

0.0001†

0.0008†

1.9 × 10-6†

rs1440095

SGK493

0.379

2

42143170

0.0098

0.1078

0.0105

rs10934938

COL29A1

0.23

3

131596325

0.1158

0.0291

0.0056

rs9402839*

MAP3K5

0.138

6

137036903

0.0355

0.0524

0.0099

rs9494554**

MAP3K5

0.095

6

137038675

0.0306

0.0035

0.0005†

rs12483377*

COL18A1

0.108

21

45755537

0.0046

0.0607

0.0030

  1. *SNPs found associated in the pooling-based GWA or their perfect tags (r2 = 0.8) used as substitutes in the genotyping design.
  2. **SNPs that remained significant after a 5% FDR in the pooling-based GWA
  3. † P-values that remain significant after Bonferroni correction (46 SNPs, p ≤ 0.001)
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BMC Medical Genetics

ISSN: 1471-2350

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