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Table 2 Transmission (T) and non transmission (NT) of IFIH1 rs1990760 polymorphism in 100 Hashimoto's thyroiditis families (Italian) according to the presence of thyroid antibodies (TPO and TG)

From: The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease

Polymorphism

Allele

Frequency

T

 

NT

 

p

pc

rs1990760

 

(%)

n

(%)

n

(%)

  

Group

A

55.5

110

(49.5)

112

(50.5)

0.84

1.68

100 parents

G

44.5

90

(50.6)

88

(49.4)

  

Group 1

A

53.2

38

(45.8)

45

(54.2)

0.26

0.52

39 mo-, fa-

G

46.8

40

(54.8)

33

(45.2)

  

Group 2

A

57.9

41

(50.6)

40

(49.4)

0.86

1.72

35 mo+, fa-

G

42.1

29

(49.2)

30

(50.8)

  

Group 3

A

66.7

10

(41.7)

14

(59.3)

0.15

0.3

9 mo-, fa+

G

33.3

8

(66.7)

4

(33.3)

  

Group 4

A

50.0

21

(61.8)

13

(38.2)

0.05*1

0.1

17 mo+, fa+

G

50.0

13

(38.2)

21

(61.8)

  
  1. mo = mothers; fa = fathers
  2. pc = p corrected
  3. *1OR = odds ratio; (95% CI) = 95% confidence interval.
  4. group 4: allele A OR 2.61 (0.98-6.94) and allele G OR 0.38 (0.14-10.2)
  5. p = 0.05