Analyses of associations between three positionally cloned asthma candidate genes and asthma or asthma-related phenotypes in a Chinese population

Table 3 Associations between SNPs in PHF11, DPP10, HLA-G and asthma or asthma-related phenotypes, adjusted for age, gender, height, weight, BMI and smoking status.

Gene	Phenotype	SNP	Genotype	Negative N (%)	Positive N (%)	OR (95% CI)	Nominal P Value
PHF11	SPT^a	rs2247119	TT	167 (35.9)	161 (30.8)	1
			CT	213 (45.8)	263 (50.3)	1.27 (0.95-1.67)	0.10
			CC	85 (18.3)	99 (18.9)	1.14 (0.79-1.65)	0.48
				Dominant Model		1.23 (0.94-1.61)	0.13
	SPT + Asthma ^b	rs2247119	TT	138 (35.8)	109 (32.2)	1
			CT	179 (46.5)	169 (49.9)	1.18 (0.84-1.65)	0.35
			CC	68 (17.7)	61 (18.0)	1.08 (0.69-1.67)	0.74
				Dominant Model		1.15 (0.84-1.58)	0.39
DPP10	MTCH Challenge^c	rs10192393	TT	404 (92.0)	393 (86.2)	1
			CT	34 (7.7)	62 (13.6)	1.91 (1.21-3.03)	0.0059
			CC	1 (0.2)	1 (0.2)	1.46 (0.09-23.56)	0.79
				Dominant Model		1.90 (1.20-3.00)	0.0059
	MTCH Challenge + Asthma ^d	rs10192393	TT	360 (92.3)	284 (85.8)	1
			CT	29 (7.4)	46 (13.9)	2.04 (1.22-3.42)	0.0070
			CC	1 (0.3)	1 (0.3)	1.66 (0.10-27.13)	0.72
				Dominant Model		2.03 (1.22-3.37)	0.0067
HLA-G	MTCH Challenge	rs1736935	CC	150 (32.6)	191 (37.5)	1
			CT	227 (49.3)	241 (47.3)	0.82 (0.61-1.09)	0.17
			TT	83 (18.0)	77 (15.1)	0.73 (0.49-1.07)	0.10
				Additive Model		0.85 (0.70-1.02)	0.079
	MTCH Challenge + Asthma	rs1736935	CC	136 (33.9)	152 (39.3)	1
			CT	192 (47.9)	181 (46.8)	0.84 (0.61-1.15)	0.27
			TT	73 (18.2)	54 (14.0)	0.64 (0.41-0.99)	0.044
				Additive Model		0.81 (0.65-0.99)	0.043

^a: Skin prick test. A positive skin prick test was defined as at least one antigen-induced wheal size >2 mm of the saline control value.
^b: Combined asthma status and skin prick test. All cases were asthmatic with a positive skin test result, while all controls were non-asthmatic with a negative skin test result.
^c: Airway methacholine challenge test. Negative and positive responses were defined as no PD₂₀ observed and a PD₂₀ observed in the test, respectively.
^d: Combined asthma status and methacholine challenge test. All cases were asthmatic with a positive challenge test result, while all controls were non-asthmatic with a negative challenge test result.

ISSN: 1471-2350