Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs

BMC Medical Genetics

Table 3 Maximum MLS and (TLS) ≥1 from the present study

Chr region	Nearest marker (cM)	ALL	SWE	UK	USA	APOE ε4+	APOE ε4-
1p36	D1S3669 (37)	-	-	3.5^b (3.3^b)	-	-	-
1p32	D1S3728 (85)	-	-	-	-	-	1.2
10p15	D10S1218 (5)	1.5^a	-	-	1.5^a	-	2.4^a (1.3)
10q22	D10S2327 (105)	-	-	-	-	-	1.8^a
10q25	D10S1237 (135)	1.3 (1.1)	-	-	1.9^a (1.4)	-	-
10q26	D10S212 (171)	(1.2)	-	-	1.1	-	-
12q13	D12S398 (68)	(1.5^a)	1.3 (1.4)	-	-	-	-
12q23	PAH (109)	-	1.1 (1.3)	-	-	-	-
12q24	D12S395 (137)	-	-	-	1.0	-	(1.6^a)
12q24	D12S392 (166)	-	1.1	-	-	-	-
19p13	D19S586 (36)	-	1.7^a	-	-	1.5	-
19q13	D19S178 (68)	3.0^b (2.5^b)	1.9^a (1.6^a)	-	1.1	8.3^b (7.3^b)	1.2
21q21	D21S1437 (13)	-	-	-	-	-	1.5^a (1.6^a)
21q22	D21S1446 (58)	(1.3)	-	-	-	1.0 (1.2)	-

Within each linkage region, the marker closest to the highest MLS has been denoted with its position in cM. Threshold levels were estimated from simulation analysis of the selected chromosomes. ^aSuggestive and ^bsignificant linkage for the respective linkage region and sample group according to Lander and Kruglyak [23].

ISSN: 1471-2350