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Table 2 Laboratory parameters of normotensive, healthy pregnant women and preeclamptic patients

From: Relationship of circulating cell-free DNA levels to cell-free fetal DNA levels, clinical characteristics and laboratory parameters in preeclampsia

Variable

Controls (n = 70)

Preeclampsia (n = 67)

Statistical significance (p value)

Serum BUN level (mmol/l)

2.7 (1.7-4.8)

3.4 (0.8-6.5)

<0.001

Serum creatinine level (μmol/l)

47 (34-79)

63 (36-95)

<0.001

Serum bilirubin level (μmol/l)

5.1 (1.8-15.2)

7.4 (2.1-20.9)

<0.001

Serum AST activity (U/l)

19 (10-38)

19 (10-148)

NS

Serum ALT activity (U/l)

12 (7-32)

15 (6-233)

<0.05

Serum LDH activity (U/l)

159 (93-211)

192 (113-403)

<0.001

Serum CRP level (mg/l)

3.6 (0.5-28.0)

6.7 (0.3-36.9)

<0.05

Plasma VWF:Ag level (%)

129.3 (47.8-297.1)

187.1 (43.3-423.0)

<0.001

Plasma fibronectin level (g/l)

0.33 (0.14-0.84)

0.58 (0.02-2.13)

<0.001

Plasma malondialdehyde level (nmol/ml)

14.74 (6.19-36.52)

18.62 (10.75-24.65)

<0.001

Plasma total DNA level (pg/μl)

11.395 (0.425-256.3)

32.460 (1.670-602.7)

<0.001

Log (total DNA level) (pg/μl) (adjusted mean ± SE)

1.145 ± 0.066

1.513 ± 0.086

<0.05

Plasma fetal DNA level (pg/μl)

0.001 (0.0-0.845)

0.086 (0.002-3.200)

<0.001

Log (fetal DNA level) (pg/μl) (adjusted mean ± SE)

-2.705 ± 0.310

-0.994 ± 0.326

<0.05

  1. Data are presented as median (range) for continuous variables
  2. NS: not significant; SE: standard error; BUN: blood urea nitrogen; AST: aspartate aminotransferase; ALT: alanine aminotransferase; LDH: lactate dehydrogenase; CRP: C-reactive protein; VWF:Ag: von Willebrand factor antigen; DNA: deoxyribonucleic acid
  3. n = 25
  4. n = 36