The pedigrees of the families carrying RyR2 R1051P (A), RyR2 S616L (B), RyR2 N3308S (C) and the RyR2 exon 3 deletions (D,E). The carrier status of the mutation is illustrated by black circles and squares. Clinically evaluated family members are shown with an asterisk. Open large squares present clinically affected individuals with CPVT phenotype, while open large circle symbolizes the disease phenotype of frequent VPCs also in resting conditions. Deceased individuals are indicated with a slash.