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Table 3 Regression analysis in European samples for all SNPs in selected subtypes.

From: Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma

  Controls   DLBCL    FL    MZ/MALT  
SNP N N OR (95% CI) p value N OR (95% CI) p value N OR (95% CI) p value
RAD50_IVS4(+19)G/A           
G/G 384 100 1 0.896 107 1 0.474 43 1 -
G/A 187 53 1.05 (0.72 - 1.54) 0.799 55 1.08 (0.74 - 1.58) 0.677 19 1.01 (0.57 - 1.80) 0.975
A/A 27 7 0.96 (0.40 - 2.30) 0.935 10 1.31 (0.61 - 2.81) 0.492 3 1.03 (0.29 - 3.61) 0.966
G/A & A/A 214        22 1.01 (0.58 - 1.76) 0.967
RAD50_IVS7(-38)C/T           
C/C 568 153 1 - 166 1 - 58 1 -
C/T 34 9 1.01 (0.47 - 2.17) 0.983 6 0.63 (0.26 - 1.53) 0.304 8 3.02 (1.28 - 7.14) 0.012
T/T 1 0 0.00 (0.00 -) 1.000 1 3.41 (0.21 - 56.13) 0.391 1 24.77 (1.43 - 427.94) 0.027
C/T & T/T 35 9 0.97 (0.45 - 2.08) 0.941 7 0.71 (0.31 - 1.64)   9 3.39 (1.48 - 7.75) 0.004
RAD50_IVS22(+24)A/G           
A/A 546 137 1 - 150 1 - 59 1 -
A/G 54 25 1.77 (1.05 - 2.96) 0.031 24 1.61 (0.96 - 2.71) 0.073 7 1.30 (0.55 - 3.04) 0.550
G/G 1 1 4.54 (0.26 - 78.43) 0.298 0 0.00 (0.00 -) 1.000 0 0.00 (0.00 -) 1.000
A/G & G/G 55 26 1.81 (1.09 - 3.01) 0.022 24 1.59 (0.94 - 2.67) 0.081 7 1.29 (0.55 - 3.02) 0.560
RAD50_IVS22(+62)A/G           
A/A 601 161 - - 174 - - 67 - -
A/G 2 2 - - 0 - - 0 - -
G/G 0 0 - - 0 - - 0 - -
NBS1_5(-905)T/C           
T/T 266 76 1 0.465 87 1 0.847 28 1 0.816
T/C 267 72 0.95 (0.66 - 1.37) 0.769 63 0.75 (0.51 - 1.08) 0.119 43 1.12 (0.65 - 1.93) 0.678
C/C 64 14 0.77 (0.41 - 1.46) 0.423 24 1.20 (0.70 - 2.06) 0.498 7 1.02 (0.42 - 2.48) 0.964
NBS1_5UTR_(-352)_del(AGTA)           
AGTA/AGTA 524 138 1 - 137 1 - 60 1 -
AGTA/- 58 16 1.06 (0.59 - 1.92) 0.839 18 1.08 (0.61 - 1.92) 0.785 2 0.30 (0.07 - 1.29) 0.105
-/- 2 0 0.00 (0.00 -) 0.999 3 5.57 (0.90 - 34.52) 0.065 0 0.00 (0.00 -) 0.999
AGTA/- & -/- 60 16 1.03 (0.57 - 1.85) 0.929 21 1.23 (0.71 - 2.11) 0.461 2 - -
NBS1_IVS3(+208)G/A           
G/G 241 66 1 0.672 84 1 0.466 26 1 0.818
G/A 277 76 1.00 (0.68 - 1.45) 0.977 63 0.67 (0.46 - 0.97) 0.033 30 0.97 (0.56 - 1.71) 0.935
A/A 78 19 0.86 (0.48 - 1.52) 0.596 27 1.04 (0.62 - 1.72) 0.892 10 1.14 (0.52 - 2.51) 0.744
NBS1_3UTR(+273)G/A           
G/G 268 78 1 0.256 90 1 0.509 26 1 0.807
G/A 263 73 0.97 (0.68 - 1.40) 0.885 54 0.65 (0.44 - 0.95) 0.026 33 1.28 (0.74 - 2.23) 0.381
A/A 63 11 0.60 (0.24 - 1.19) 0.142 24 1.12 (0.66 - 1.91) 0.669 6 0.89 (0.35 - 2.29) 0.813
NBS1_X2_(102)_G/A           
G/G 266 75 1 0.521 87 1 0.935 28 1 0.698
G/A 272 72 0.95 (0.66 - 1.37) 0.782 62 0.72 (0.50 - 1.04) 0.082 33 1.15 (0.67 - 1.97) 0.615
A/A 59 13 0.79 (0.41 - 1.53) 0.486 24 1.31 (0.76 - 2.25) 0.326 7 1.09 (0.45 - 2.67) 0.849
NBS1_X5_(553)_G/C           
G/G 255 76 1 0.306 84 1 0.786 28 1 0.938
G/C 270 72 0.90 (0.62 - 1.30) 0.572 62 0.73 (0.50 - 1.06) 0.098 33 1.12 (0.65 - 1.92) 0.688
C/C 57 12 0.70 (0.36 - 1.39) 0.310 22 1.22 (0.70 - 2.13) 0.486 6 0.92 (0.36 - 2.36) 0.857
NBS1_X13_(2016)_A/G           
A/A 247 74 1 0.204 83 1 0.634 27 1 0.897
A/G 265 70 0.89 (0.61 - 1.30) 0.549 59 0.69 (0.47 - 1.01) 0.055 33 1.13 (0.65 - 1.95) 0.671
G/G 55 10 0.61 (0.29 - 1.26) 0.180 21 1.20 (0.68 - 2.12) 0.537 6 0.94 (0.36 - 2.43) 0.902
MRE11_5(-1703)A/G           
A/A 261 76 1 0.431 81 1 0.725 25 1 0.100
A/G 267 60 0.91 (0.63 - 1.32) 0.629 69 0.84 (0.58 - 1.21) 0.341 29 1.20 (0.68 - 2.13) 0.527
G/G 66 15 0.79 (0.42 - 1.47) 0.457 22 1.03 (0.59 - 1.78) 0.919 13 1.95 (0.93 - 4.10) 0.076
MRE11_5(-1456)C/T           
C/C 582 153 1 - 165 1 - 67 - -
C/T 21 9 1.76 (0.78 - 3.96) 0.173 9 1.38 (0.61 - 3.09) 0.441 1 - -
T/T 1 1 4.32 (0.26 - 72.48) 0.309 0 0.00 (0.00 -) 0.100 0 - -
C/T & T/T 22 10 1.87 (0.86 - 4.08) 0.115 9 1.34 (0.60 - 2.99) 0.481    
MRE11_IVS2(+28)G/A           
G/G 189 51 1 0.751 54 1 0.967 17 1 0.144
G/A 277 81 1.07 (0.72 - 1.59) 0.753 85 1.10 (0.75 - 1.63) 0.623 32 1.42 (0.75 - 2.66) 0.279
A/A 124 30 0.90 (0.54 - 1.49) 0.675 34 0.99 (0.61 - 1.61) 0.959 18 1.69 (0.83 - 3.46) 0.150
MRE11_IVS9(-60)A/T           
T/T 270 82 1 0.419 77 1 0.866 27 1 0.625
T/A 255 61 0.75 (0.51 - 1.09) 0.130 79 1.15 (0.80 - 1.66) 0.453 29 1.19 (0.68 - 2.11) 0.542
A/A 70 20 0.96 (0.55 - 1.68) 0.877 17 0.82 (0.45 - 1.47) 0.498 9 1.14 (0.51 - 2.58) 0.752
BLM_IVS7(+388)C/T           
C/C 517 140 1 - 148 1 - 62 1 -
C/T 78 22 1.04 (0.62 - 1.73) 0.891 24 1.03 (0.63 - 1.70) 0.908 6 0.62 (0.26 - 1.49) 0.284
T/T 3 0 0.00 (0.00 -) 0.999 1 0.96 (0.10 - 9.65) 0.970 0 0.00 (0.00 -) 0.999
C/T & T/T 81 22 1.01 (0.60 - 1.68) 0.978 25 1.03 (0.623- 1.68) 0.915 6 0.59 (0.25 - 1.43) 0.244
BLM_IVS7(+798)ins(T)           
T/T 528 145 1 - 156 1 - 62 1 -
T/- 69 17 0.89 (0.51 - 1.57) 0.689 17 0.90 (0.51 - 1.58) 0.702 5 0.71 (0.27 - 1.84) 0.474
-/- 4 0 0.00 (0.00 -) 0.999 1 1.09 (0.12 - 10.39) 0.939 0 0.00 (0.00 -) 0.999
T/- & -/- 73 17 0.84 (0.48 - 1.47) 0.534 18 0.90 (0.52 - 1.58) 0.722 5 0.67 (0.26 - 1.75) 0.418
BLM_IVS12(+7)T/C           
T/T 316 88 1 0.944 88 1 0.696 33 1 0.609
T/C 243 58 0.85 (0.58 - 1.23) 0.389 68 0.99 (0.69 - 1.43) 0.975 29 1.18 (0.69 - 2.02) 0.546
C/C 45 15 1.23 (0.55 - 2.32) 0.533 16 1.21 (0.65 - 2.26) 0.554 5 1.12 (0.41 - 3.07) 0.823
BLM_IVS21(-60)_del(GAA)           
GAA/GAA 237 61 1 0.968 74 1 0.727 37 1 0.026
GAA/- 283 81 1.09 (0.75 - 1.60) 0.640 75 0.87 (0.60 - 1.26) 0.452 21 0.46(0.26 - 0.82) 0.008
-/- 76 19 0.94 (0.53 - 1.69) 0.840 24 0.98 (0.58 - 1.68) 0.949 8 0.56 (0.24 - 1.27) 0.162
  1. OR = Odds Ratio, CI = Confidence Interval, DLBCL = Diffuse Large B-Cell Lymphoma, FL = Follicular Lymphoma, MZ/MALT = Marginal Zone lymphoma/Mucosa-Associated Lymphoma Tissue lymphoma.
  2. If less than 5 samples were in a category, the analysis is not valid and marked by "-". Analyses were not done for subtypes that had fewer than 5 heterozygotes and minor homozygotes combined. Analysis is adjusted for adjusted for gender, ethnicity, age, and residence.
  3. p-value for test for trend is shown in italic type.
  4. p-values less than 0.05 are in bold.
  5. All results are in Additional file 9.