PLAURpolymorphisms and lung function in UK smokers

BMC Medical Genetics

Table 1 Baseline characteristics of study cohorts

	Smokers (n = 992)	Controls (n = 176)	COPD (n = 599)	Male Smokers (n = 553)	Female Smokers (n = 431)
Age in years (mean ± SD)	63.33 ± 10.28 (992)	54.38 ± 9.52	65.96 ± 9.01	64.98 ± 10.01	61.23 ± 10.32
Female (%)	43.8 (984)	56.3	40.4	0	100
% predicted FEV₁ (mean ± SD)	56.01 ± 28.17 (975)	96.03 ± 12.15	40.31 ± 15.63	52.82 ± 26.87	60.24 ± 29.43
FEV₁/FVC Ratio (mean ± SD)	55.3 ± 17.4 (971)	77.3 ± 5.9	46.3 ± 12.6	53.7 ± 17.3	57.5 ± 17.5
Post BD % predicted FEV₁ (mean ± SD)	59.08 ± 27.14 (885)	99.48 ± 11.72	44.65 ± 15.52	55.34 ± 25.46	64.10 ± 28.55
Post BD FEV₁/FVC Ratio (mean ± SD)	55.6 ± 17.7 (873)	79.1 ± 5.5	46.2 ± 12.0	53.2 ± 17.6	58.6 ± 17.6
Pack Years (mean ± SD)	43.52 ± 26.05 (969)	32.74 ± 20.04	47.61 ± 27.01	48.72 ± 28.53	36.65 ± 20.66

FEV₁ Forced expiratory volume in one second, FVC forced vital capacity. Number in brackets represents data available for that variable. Continual variables between Controls and COPD groups were compared by independent T-Test, categorical variables by Pearson chi square (all variables p < 0.0001). Similarly, all variables between males and females were statistically different.

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