Figure 1

Schematic representation of the PLAUR gene and haplotype block structure of PLAUR SNPs in smokers. (A) Schematic representation of the PLAUR gene on chromosome 19 illustrating the position of SNPs 1-13 (see Table 2). SNPs 14-25 located in the promoter region/5'region are omitted for clarity. The PLAUR gene is displayed in the reverse orientation to that observed on chromosome 19 (~40 kb). Exons are depicted as open boxes except for alternatively spliced exon 7 (VIIB, grey, see [34]). (B) Haplotype block structure of all 25 SNPs on Chromosome 19 in smokers (n = 992). The colour of shading represents R² (a measure of LD) and numerical values are given (generated using Haploview software [13]). Haplotype blocks were defined using confidence intervals for strong LD D' 0.7-0.98.