Table 3 Odds Ratios of low-GFR cases (GFR < 75 ml/min/1.73 m2) by the MDRD equation and CKD-EPI formula associated with the e2 allele, e4 allele, and APOE score in NHANES III Genetic Study (1991-1994) participants by ethnicity

Non-Hispanic white

MDRD equation

   Crude

1.08

0.81, 1.45

0.76*

0.60, 0.97

1.21*

1.01, 1.45

   Minimally adjusted

0.96

0.66, 1.39

0.82

0.60, 1.14

1.10

0.88, 1.38

   Final

0.99

0.69, 1.44

0.83

0.60, 1.15

1.11

0.87, 1.42

CKD-EPI formula

   Crude

1.21

0.82, 1.79

0.72*

0.59, 0.88

1.31*

1.06, 1.60

   Minimally adjusted

1.10

0.61, 1.99

0.82

0.65, 1.05

1.16

0.90, 1.50

   Final

1.12

0.59, 2.14

0.77

0.58, 1.02

1.22

0.92, 1.62

Non-Hispanic black

MDRD equation

   Crude

1.45

0.91, 2.33

0.95

0.69, 1.32

1.19

0.96, 1.49

   Minimally adjusted

1.50

0.91, 2.50

1.01

0.72, 1.42

1.16

0.92, 1.46

   Final

1.37

0.79, 2.38

1.07

0.75, 1.53

1.08

0.87, 1.36

CKD-EPI formula

   Crude

1.29

0.69, 2.41

0.88

0.67, 1.18

1.19

0.89, 1.59

   Minimally adjusted

1.42

0.73, 2.76

0.92

0.70, 1.21

1.20

0.86, 1.68

   Final

1.26

0.63, 2.52

0.94

0.68, 1.29

1.13

0.83, 1.57

Mexican American

MDRD equation

   Crude

0.71

0.34, 1.48

1.12

0.69, 1.79

0.85

0.57, 1.28

   Minimally adjusted

0.77

0.34, 1.72

1.13

0.71, 1.82

0.85

0.57, 1.28

   Final

0.77

0.34, 1.81

1.14

0.71, 1.86

0.85

0.57, 1.27

CKD-EPI formula

   Crude

0.90

0.45, 1.80

0.90

0.48, 1.66

1.05

0.66, 1.67

   Minimally adjusted

0.97

0.44, 2.12

0.92

0.43, 1.99

1.05

0.62, 1.79

   Final

0.95

0.37, 2.42

0.85

0.39, 1.85

1.10

0.66, 1.84