Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study

Gallicchio, Lisa; Chang, Howard H; Christo, Dana K; Thuita, Lucy; Huang, Han Yao; Strickland, Paul; Ruczinski, Ingo; Clipp, Sandra; Helzlsouer, Kathy J

doi:10.1186/1471-2350-10-103

Table 2 Associations of obesity-related SNPs with BMI, change in BMI, and risk of becoming overweight

From: Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study

		BMI (kg/m²) at baseline (1989)		BMI change from age 21 to baseline (1989)		BMI ≥25 kg/m² at baseline (1989) among those with BMI <25 kg/m² at age 21^a
Gene	rs #	Difference in mean^b (95% CI)	p-value	Difference in mean^b (95% CI)	p-value	Odds ratio^b (95% CI)	p-value
PPARG	4684847		0.36		0.57		0.20
CC		Reference		Reference		1.00 (reference)
CT		0.18 (-0.07, 0.43)		-0.07 (-0.30, 0.15)		1.06 (0.95, 1.20)
TT		0.17 (-0.67, 1.02)		0.30 (-0.45, 1.06)		1.35 (0.91, 2.01)
PPARG	709158		0.88		0.59		0.86
AA		Reference		Reference		1.00 (reference)
GA		0.05 (-0.16, 0.27)		0.09 (-0.10, 0.28)		0.97 (0.88, 1.07)
GG		0.02 (-0.29, 0.33)		0.11 (-0.17, 0.39)		0.99 (0.86, 1.14)
PPARG	1175543		0.99		0.52		0.79
AA		Reference		Reference		1.00 (reference)
AG		-0.01 (-0.22, 0.20)		0.05 (-0.14, 0.24)		0.97 (0.88, 1.07)
GG		-0.03 (-0.34, 0.29)		0.16 (-0.12, 0.44)		0.99 (0.85, 1.14)
PPARG	1801282		0.69		0.70		0.01
CC		Reference		Reference		1.00 (reference)
CG		0.09 (-0.16, 0.34)		-0.02 (-0.24, 0.20)		1.03 (0.92, 1.16)
GG		0.23 (-0.6, 1.06)		0.31 (-0.44, 1.06)		1.91 (1.28, 2.88)
PPARD	2016520		0.61		0.40		0.54
TT		Reference		Reference		1.00 (reference)
CT		-0.09 (-0.31, 0.12)		-0.13 (-0.32, 0.06)		0.97 (0.88, 1.07)
CC		0.11 (-0.42, 0.64)		-0.08 (-0.56, 0.39)		1.10 (0.86, 1.41)
LPL	316		0.39		0.55		0.78
CC		Reference		Reference		1.00 (reference)
AC		0.07 (-0.17, 0.31)		0.1 (-0.09, 0.29)		1.03 (0.94, 1.14)
AA		0.53 (-0.28, 1.34)		0.01 (-0.28, 0.30)		1.00 (0.86, 1.16)
PON1	662		0.61		0.59		0.75
TT		Reference		Reference		1.00 (reference)
CT		-0.08 (-0.29, 0.12)		0.10 (-0.11, 0.32)		1.04 (0.93, 1.17)
CC		-0.14 (-0.51, 0.22)		-0.12 (-0.85, 0.60)		0.96 (0.65, 1.40)
LEPR	7602		0.47		0.71		0.34
GG		Reference		Reference		1.00 (reference)
AG		-0.14 (-0.35, 0.08)		-0.06 (-0.24, 0.13)		0.93 (0.85, 1.02)
AA		-0.05 (-0.55, 0.45)		0.07 (-0.26, 0.39)		0.98 (0.83, 1.16)
LEPR	1045895		0.69		0.01		0.12
GG		Reference		Reference		1.00 (reference)
AG		0.08 (-0.14, 0.30)		-0.28 (-0.47, -0.09)		0.93 (0.84, 1.03)
AA		-0.02 (-0.31, 0.28)		-0.30 (-0.75, 0.15)		1.16 (0.92, 1.48)
LEPR	1137101		0.02		0.04		0.39
AA		Reference		Reference		1.00 (reference)
AG		-0.18 (-0.41, 0.05)		0.22 (0.03, 0.42)		1.07 (0.97, 1.19)
GG		0.18 (-0.11, 0.46)		0.26 (0.00, 0.53)		1.05 (0.92, 1.21)
PON2	7493		0.50		0.18		0.27
GG		Reference		Reference		1.00 (reference)
CG		0.02 (-0.19, 0.23)		-0.17 (-0.38, 0.04)		0.94 (0.85, 1.05)
CC		0.27 (-0.18, 0.72)		0.00 (-0.26, 0.25)		1.03 (0.90, 1.18)
PON2	12026		0.59		0.64		0.05
CC		Reference		Reference		1.00 (reference)
CG		0.03 (-0.18, 0.24)		0.08 (-0.10, 0.27)		1.08 (0.98, 1.19)
GG		0.23 (-0.22, 0.68)		0.11 (-0.29, 0.51)		1.25 (1.02, 1.55)
TNFα	1800629		0.27		0.56		0.07
GG		Reference		Reference		1.00 (reference)
GA		0.15 (-0.07, 0.38)		0.09 (-0.09, 0.28)		1.08 (0.98, 1.19)
AA		-0.22 (-0.82, 0.39)		0.13 (-0.27, 0.54)		1.23 (1.00, 1.51)
TNFα	1799724		0.19		0.19		0.06
CC		Reference		Reference		1.00 (reference)
CT		-0.24 (-0.50, 0.02)		0.19 (-0.01, 0.38)		1.11 (1.00, 1.23)
TT		0.11 (-0.91, 1.13)		0.07 (-0.47, 0.62)		0.84 (0.63, 1.12)
TNFα	1799964		0.06		0.31		0.87
TT		Reference		Reference		1.00 (reference)
CT		0.22 (0.01, 0.43)		-0.18 (-0.42, 0.06)		1.01 (0.89, 1.14)
CC		-0.16 (-0.61, 0.29)		0.11 (-0.81, 1.03)		0.88 (0.55, 1.40)
MAOA (F)	1801291		0.45		0.30		0.82
CC		Reference		Reference		1.00 (reference)
CT		0.16 (-0.13, 0.45)		0.10 (-0.09, 0.29)		1.02 (0.93, 1.13)
TT		-0.10 (-0.61, 0.42)		-0.19 (-0.60, 0.21)		0.96 (0.78, 1.18)
MAOA (M)	1801291		NA		NA		NA
CC		Reference		Reference		1.00 (reference)
TT		-0.07 (-0.36, 0.22)		0.08 (-0.17, 0.33)		1.02 (0.90, 1.15)

95% CI, 95% confidence interval; NA, not applicable
^a n = 7970 with self-reported BMI < 25 kg/m2 at age 21
^b Adjusted for age and gender

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