An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1gene

Ramagopalan, Sreeram V; McMahon, Roisin; Dyment, David A; Sadovnick, A Dessa; Ebers, George C; Wittkowski, Knut M

doi:10.1186/1471-2350-10-10

Table 2 Test statistics for specific alleles at any of the 93 SNPs increasing (positive) or decreasing (negative) the risk of MS.

From: An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1gene

	#N	#A	A	C	G	T		A	C	G	T
1	14	-25	6.723		-6.723		1231	0.506		-0.506		995
2	16	-24		4.485		-4.485	747		0.512		-0.512	593
3	37	-17	12.563		*-12.563*		1249	1.774		-1.774		1018
4	41	-16		6.723		-6.723	1231		0.506		-0.506	995
5	42	-16			12.563	*-12.563*	1249			1.774	-1.774	1018
6	85	-1			*-15.587*	15.587	1139			*-2.985*	2.985	926
7	97	4	-6.723	6.723			1231	-0.506	0.506			995
8	98	4	-3.206		3.206		696	-1.308		1.308		547
9	109	8		11.817		-11.817	1311		1.629		-1.629	1028
10	112	9	-1.313		-9.607	9.830	1340	0.354		-0.829	0.776	1066
11	115	10		6.723	-1.000	-6.565	1245		0.506	0.316	-0.562	1004
12	117	10		-6.565	6.565		1236		-0.562	0.562		993
13	118	11		12.563	-6.002	-6.565	1544		1.774	-1.323	-0.562	1245
14	119	11	-1.313	7.597	-2.961	-6.254	1360	0.354	2.093	-1.418	-1.354	1073
15	122	12	6.565	-6.565			1236	0.562	-0.562			993
16	124	13	14.806	-5.027	-1.172	-9.371	1425	3.079	-0.726	0.884	*-2.514*	1133
17	125	13	-6.121	-5.444	13.465	-4.346	1507	-1.794	-0.856	3.240	-1.205	1225
18	126	13			15.117	*-15.117*	1171			2.781	*-2.781*	961
19	127	14	-2.961		2.961		657	-1.418		1.418		528
20	129	14	-3.750		3.750		544	-1.403		1.403		455
21	133	16		1.172		-1.172	236		-0.884		0.884	155
22	144	19		-6.002		6.002	1118		-1.323		1.323	897
23	164	26				0.156	41	0.730			-0.730	30
24	165	26		4.739	-3.887	-1.313	663	1.508	0.732	-1.289	0.354	531
25	169	28		-1.313	1.313		58		0.354	-0.354		32
26	171	28	-4.609	4.964	-1.732		395	-0.967	0.981	0.000		310
27	175	30		-3.790	-1.313	4.009	770		-0.885	0.354	0.792	617
28	176	30	5.203		-4.158	-2.961	1055	1.941		-1.169	-1.418	857
29	178	31	-4.029		-1.000	4.158	605	-1.277		0.316	1.169	505
30	181	32		-1.742		1.742	309		0.000		0.000	255
31	184	33	4.485	-4.485			747	0.512	-0.512			593
32	189	34	-5.998		5.998		425	-0.372		0.372		348
33	196	37					18					9
34	197	37	-1.897	3.130		-2.629	71	-0.333	1.386		-1.361	58
35	199	38		-2.438	2.438		88		1.508	-1.508		44
36	200	38		-1.000		1.000	36		0.316		-0.316	40
37	227	47	-4.743			4.743	116	-2.008			2.008	87
38	246	53	-2.961		2.961		657	-1.418		1.418		528
40	257	57	4.879			-4.879	208	3.048			*-3.048*	153
41	258	57		-1.121		1.121	29		-1.291		1.291	11
42	260	58	-4.929	4.929			461	0.246	-0.246			390
43	261	58		-0.775	0.000	1.134	9		0.258	0.000	-0.577	9
45	266	60	2.863	-2.863			488	2.066	-2.066			373
46	286	67	-0.447	0.447			5	-0.577	0.577			3
47	294	69	-0.956		0.956		67	-0.117		0.117		49
48	295	70		2.656	-2.656		69		0.289	-0.289		39
49	296	70	1.877		-1.877		92	-0.367		0.367		67
50	297	70		-6.363	6.363		428		-1.261	1.261		300
52	299	71	-0.884	4.447	-4.196		159	-0.717	2.535	-2.137		96
54	305	73		2.218	-2.218		1086		1.724	-1.724		903
55	307	74		-3.558	3.558		203		*-2.571*	2.571		139
56	308	74	-2.333	2.333			72	-1.477	1.477			55
57	317	77	-1.191	1.191			273	-0.931	0.931			186
59	320	78	1.121			-1.121	39	-0.426			0.426	22
60	321	78		2.183	-2.183		17		0.632	-0.632		10
62	344	86			-1.414	1.414	2			0.000	0.000	0
64	365	93	-1.313	1.313			58	0.354	-0.354			32
65	372	95		3.887		-3.887	566		1.289		-1.289	476
66	373	96		6.168	-3.750	-4.485	1085		1.428	-1.403	-0.512	880
67	375	96	14.920		-3.750	*-12.385*	1386	2.799		-1.403	-1.818	1135
68	379	98	5.914		-5.914		1106	1.400		-1.400		887
69	390	101	15.117		*-15.117*		1171	2.781		*-2.781*		961
70	397	104			-5.914	5.914	1106			-1.400	1.400	887
71	405	106		3.206		-3.206	696		1.308		-1.308	547
73	438	117		6.723		-6.723	1231		0.506		-0.506	995
74	446	120	-4.595		4.595		769	-0.422		0.422		609
75	484	133			*-15.117*	15.117	1171			*-2.781*	2.781	961
76	489	134		6.565		-6.565	1236		0.562		-0.562	993
77	505	140	-9.607		9.607		1325	-0.829		0.829		1057
78	511	142	15.117		*-15.117*		1171	2.781		*-2.781*		961
79	522	145	2.573		-2.573		121	-1.342		1.342		82
80	534	149		-6.565	6.565		1236		-0.562	0.562		993
81	543	152		3.750		-3.750	544		1.403		-1.403	455
82	584	166	-1.000		1.000		36	0.316		-0.316		40
83	585	166	15.117		*-15.117*		1171	2.781		*-2.781*		961
84	594	166	-3.206		3.206		696	-1.308		1.308		547
85	624	179		5.203		-5.203	1003		1.941		-1.941	816
86	625	180		-4.485	4.485		747		-0.512	0.512		593
87	629	181		3.348		-3.348	718		1.199		-1.199	581
88	630	181	7.597		-7.597		1248	2.093		-2.093		999
89	656	190	-0.450			0.450	180	-0.616			0.616	132
90	707	207		-6.168		6.168	1032		-1.428		1.428	823
91	739	218		2.961		-2.961	657		1.418		-1.418	528
92	783	232	1.000	-1.000			36	-0.316	0.316			40
93	789	234		6.813	-6.813		1207		0.771	-0.771		989

Left side: analysis of cases, right side: analysis of unaffected siblings.

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ISSN: 1471-2350

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