Skip to main content

Table 2 Test statistics for specific alleles at any of the 93 SNPs increasing (positive) or decreasing (negative) the risk of MS.

From: An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1gene

  #N #A A C G T   A C G T  
1 14 -25 6.723   -6.723   1231 0.506   -0.506   995
2 16 -24   4.485   -4.485 747   0.512   -0.512 593
3 37 -17 12.563   -12.563   1249 1.774   -1.774   1018
4 41 -16   6.723   -6.723 1231   0.506   -0.506 995
5 42 -16    12.563 -12.563 1249    1.774 -1.774 1018
6 85 -1    -15.587 15.587 1139    -2.985 2.985 926
7 97 4 -6.723 6.723    1231 -0.506 0.506    995
8 98 4 -3.206   3.206   696 -1.308   1.308   547
9 109 8   11.817   -11.817 1311   1.629   -1.629 1028
10 112 9 -1.313   -9.607 9.830 1340 0.354   -0.829 0.776 1066
11 115 10   6.723 -1.000 -6.565 1245   0.506 0.316 -0.562 1004
12 117 10   -6.565 6.565   1236   -0.562 0.562   993
13 118 11   12.563 -6.002 -6.565 1544   1.774 -1.323 -0.562 1245
14 119 11 -1.313 7.597 -2.961 -6.254 1360 0.354 2.093 -1.418 -1.354 1073
15 122 12 6.565 -6.565    1236 0.562 -0.562    993
16 124 13 14.806 -5.027 -1.172 -9.371 1425 3.079 -0.726 0.884 -2.514 1133
17 125 13 -6.121 -5.444 13.465 -4.346 1507 -1.794 -0.856 3.240 -1.205 1225
18 126 13    15.117 -15.117 1171    2.781 -2.781 961
19 127 14 -2.961   2.961   657 -1.418   1.418   528
20 129 14 -3.750   3.750   544 -1.403   1.403   455
21 133 16   1.172   -1.172 236   -0.884   0.884 155
22 144 19   -6.002   6.002 1118   -1.323   1.323 897
23 164 26     0.156 41 0.730    -0.730 30
24 165 26   4.739 -3.887 -1.313 663 1.508 0.732 -1.289 0.354 531
25 169 28   -1.313 1.313   58   0.354 -0.354   32
26 171 28 -4.609 4.964 -1.732   395 -0.967 0.981 0.000   310
27 175 30   -3.790 -1.313 4.009 770   -0.885 0.354 0.792 617
28 176 30 5.203   -4.158 -2.961 1055 1.941   -1.169 -1.418 857
29 178 31 -4.029   -1.000 4.158 605 -1.277   0.316 1.169 505
30 181 32   -1.742   1.742 309   0.000   0.000 255
31 184 33 4.485 -4.485    747 0.512 -0.512    593
32 189 34 -5.998   5.998   425 -0.372   0.372   348
33 196 37      18      9
34 197 37 -1.897 3.130   -2.629 71 -0.333 1.386   -1.361 58
35 199 38   -2.438 2.438   88   1.508 -1.508   44
36 200 38   -1.000   1.000 36   0.316   -0.316 40
37 227 47 -4.743    4.743 116 -2.008    2.008 87
38 246 53 -2.961   2.961   657 -1.418   1.418   528
40 257 57 4.879    -4.879 208 3.048    -3.048 153
41 258 57   -1.121   1.121 29   -1.291   1.291 11
42 260 58 -4.929 4.929    461 0.246 -0.246    390
43 261 58   -0.775 0.000 1.134 9   0.258 0.000 -0.577 9
45 266 60 2.863 -2.863    488 2.066 -2.066    373
46 286 67 -0.447 0.447    5 -0.577 0.577    3
47 294 69 -0.956   0.956   67 -0.117   0.117   49
48 295 70   2.656 -2.656   69   0.289 -0.289   39
49 296 70 1.877   -1.877   92 -0.367   0.367   67
50 297 70   -6.363 6.363   428   -1.261 1.261   300
52 299 71 -0.884 4.447 -4.196   159 -0.717 2.535 -2.137   96
54 305 73   2.218 -2.218   1086   1.724 -1.724   903
55 307 74   -3.558 3.558   203   -2.571 2.571   139
56 308 74 -2.333 2.333    72 -1.477 1.477    55
57 317 77 -1.191 1.191    273 -0.931 0.931    186
59 320 78 1.121    -1.121 39 -0.426    0.426 22
60 321 78   2.183 -2.183   17   0.632 -0.632   10
62 344 86    -1.414 1.414 2    0.000 0.000 0
64 365 93 -1.313 1.313    58 0.354 -0.354    32
65 372 95   3.887   -3.887 566   1.289   -1.289 476
66 373 96   6.168 -3.750 -4.485 1085   1.428 -1.403 -0.512 880
67 375 96 14.920   -3.750 -12.385 1386 2.799   -1.403 -1.818 1135
68 379 98 5.914   -5.914   1106 1.400   -1.400   887
69 390 101 15.117   -15.117   1171 2.781   -2.781   961
70 397 104    -5.914 5.914 1106    -1.400 1.400 887
71 405 106   3.206   -3.206 696   1.308   -1.308 547
73 438 117   6.723   -6.723 1231   0.506   -0.506 995
74 446 120 -4.595   4.595   769 -0.422   0.422   609
75 484 133    -15.117 15.117 1171    -2.781 2.781 961
76 489 134   6.565   -6.565 1236   0.562   -0.562 993
77 505 140 -9.607   9.607   1325 -0.829   0.829   1057
78 511 142 15.117   -15.117   1171 2.781   -2.781   961
79 522 145 2.573   -2.573   121 -1.342   1.342   82
80 534 149   -6.565 6.565   1236   -0.562 0.562   993
81 543 152   3.750   -3.750 544   1.403   -1.403 455
82 584 166 -1.000   1.000   36 0.316   -0.316   40
83 585 166 15.117   -15.117   1171 2.781   -2.781   961
84 594 166 -3.206   3.206   696 -1.308   1.308   547
85 624 179   5.203   -5.203 1003   1.941   -1.941 816
86 625 180   -4.485 4.485   747   -0.512 0.512   593
87 629 181   3.348   -3.348 718   1.199   -1.199 581
88 630 181 7.597   -7.597   1248 2.093   -2.093   999
89 656 190 -0.450    0.450 180 -0.616    0.616 132
90 707 207   -6.168   6.168 1032   -1.428   1.428 823
91 739 218   2.961   -2.961 657   1.418   -1.418 528
92 783 232 1.000 -1.000    36 -0.316 0.316    40
93 789 234   6.813 -6.813   1207   0.771 -0.771   989
  1. Left side: analysis of cases, right side: analysis of unaffected siblings.