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Table 1 Nucleotides (N#: nucleotide number, #A: amino acid number) found in 94 HLA-DRB1 SNPs discriminating the 13 main two-digit allelic groups (rows).

From: An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1gene

Allelotype: 02 01 04 03 05 06 08 10 09 07
A# N# 15 16    17/18 11 12 13 14     
-25 14 A A A A G G G G G G G A A
-24 16 C C C T C C C C C C C C C
-17 37 A A A G G G G G G G G G G
-16 41 C C C C T T T T T T T C C
-16 42 G G G T T T T T T T T T T
-1 85 T G G G G G G G G G G G G
-1 86 C C C C C C C C C C C C C
-1 87 T T T T T T T T T T T T T
4 97 C C C C A A A A A A A C C
4 98 G G G G G G G G G G G A A
8 109 C C T T T T T T T T T T C
9 112 T T T G G G G G G G G A T
10 115 C C C C T T T T T T G C C
10 117 G G G G C C C C C C G G G
11 118 C C C G T T T T T T G G G
11 119 C C T T C C C C C C T A G
12 122 A A A A C C C C C C A A A
13 124 A A T C T T G T TG G T T T
13 125 G G T A C C G C CG G T T A
13 126 G G T T T T T T T T T T T
14 127 G G G G G G G G G G G G A
14 129 G G A G G G G G G G G G G
16 133 C C C C C C T C CT T C C C
19 144 T T T C T T T T T T C C C
26 164 T T T T AT T T T T T T A T
26 165 C C G C C C A C C C G T C
28 169 G G G G G G G G G G G C G
28 171 C C A C CG C G CG CG C A C A
30 175 T T T T T T C T T T C G C
30 176 A A G A A A A A A A G G T
31 178 T T A T T T T T T T G A T
32 181 T T T T C CT C CT CT CT C T T
33 184 A A A C A A A A A A A A A
34 189 G G A A G AG G AG AG AG A A G
37 196 T T T T AT AT CT AT AT T T A T
37 197 C C C AC AT AT T AT AT AT A A T
38 199 G G G G G G C G G G G G G
38 200 T T T T T T T T T T C T T
47 227 T AT A AT AT AT T AT AT A A A A
53 246 G G G G G G G G G G G G A
57 256 G G G AG G G G AG AG AG G G G
57 257 A A A AG A A AT ATG AC ATG A T T
57 258 CT C T CT T T CT CT CT CT T C C
58 260 C C C C C A C C C C C C C
58 261 CT T C CTG CG G C CT CTG CG C C C
60 265 T T T T T T T T CT T T T T
60 266 A A A A A A AC AC A A A C C
60 267 A A A A A A A A A A A A A
67 286 AC ACT AC ACT C ACT AT ACT ACT AT C T A
69 294 AG A G AG G AG A A AG A G G G
70 295 CG G C CG C CG G G CG G C C G
70 296 A A A A A A A A AG A G G A
70 297 G C G CG G CG C C CG C G G C
71 298 AG A AG AG A AG A AG AG A A A A
71 299 C G ACG AG A AG G AG AG G G G G
72 303 G CG G G G G CG CG G G CT G G
73 305 C C C C G C C C C C C C G
74 307 G G G CG C CG G CG CG CG G G C
74 308 C C C ACT AG ACT C CT ACT CT C A A
77 317 C C AC AC A C C C AC C C C C
77 318 C C CT C CT C C C C C C C C
78 320 A A A A A A A A A A A T AT
78 321 C C CT C C CT CT C CT C C G CG
85 341 T T CT T T CT CT T T T T T T
86 344 TG T TG TG TG TG G TG TG TG TG T T
90 357 A A A AG A AG A AG A AG A A A
93 365 C C C C C C C C C C C A C
95 372 C C T C C C C C C C T C C
96 373 C C G T C C C C C C C C C
96 374 A A A A A A A A A A A A A
96 375 A A G T T T T T T T A T T
98 379 A A A G A A A A A A A G G
101 388 G G G G G G G G G G G G G
101 389 T T T T T T T T T T T T T
101 390 A A G G G G G G G G G G G
104 397 T T T G T T T T T T T G G
106 405 C C C C C C C C C C C T T
114 429 C C C C C C C C CG C C C C
117 438 C C C C T T T T T T T C C
120 446 G G G A G G G G G G A G G
133 484 C C C C C C C C C C C C C
133 485 T T G G G G G G G G G G G
133 486 G G G G G G G G G G G G G
134 489 C C C C T T T T T T C C C
140 505 G G G A A A A A A A A G G
142 511 A A G G G G G G G G G G G
142 512 T T T T T T T T T T T T T
142 513 G G G G G G G G G G G G G
145 522 A A A A A A G A A A G A A
149 534 G G G G C C C C C C G G G
152 543 C C T C C C C C C C C C C
166 583 C C C C C C C C C C C C C
166 584 G G G G G G G G G G A G G
166 585 A A G G G G G G G G G G G
169 594 G G G G G G G G G G G A A
179 624 C C T C C C C C C C T T T
180 625 G G G C G G G G G G G G G
181 629 C C C C C C C C C C T T T
181 630 A A G G A A A A A A G G G
190 656 A A A A A A A A A T A A A
207 707 T T C C T T T T T T T T T
218 739 C C C C C C C C C C C C T
232 783 A A A A A A A A A A C A A
234 789 C C C C G G G G G C C C C
#Cases:   3994 208 1396 1982 1873 1068 146 1519 243 408 80 98 1653
  1. Note that many SNPs have more than two nucleotides and some SNPs have several nucleotides for the same allelic group. For instance, Nucleotide 257 can be either A or T within allelotype *12 and A, T, or G within allelotype *13. Given the high prevalence of the HLA-DRB1*15 (15) allele, the nucleotide found in this group of alleles was used as the reference, unless several nucleotides were found in the alleles constituting the HLA-DRB1*15 group.