Skip to main content

Table 1 Nucleotides (N#: nucleotide number, #A: amino acid number) found in 94 HLA-DRB1 SNPs discriminating the 13 main two-digit allelic groups (rows).

From: An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1gene

Allelotype:

02

01

04

03

05

06

08

10

09

07

A#

N#

15

16

  

17/18

11

12

13

14

    

-25

14

A

A

A

A

G

G

G

G

G

G

G

A

A

-24

16

C

C

C

T

C

C

C

C

C

C

C

C

C

-17

37

A

A

A

G

G

G

G

G

G

G

G

G

G

-16

41

C

C

C

C

T

T

T

T

T

T

T

C

C

-16

42

G

G

G

T

T

T

T

T

T

T

T

T

T

-1

85

T

G

G

G

G

G

G

G

G

G

G

G

G

-1

86

C

C

C

C

C

C

C

C

C

C

C

C

C

-1

87

T

T

T

T

T

T

T

T

T

T

T

T

T

4

97

C

C

C

C

A

A

A

A

A

A

A

C

C

4

98

G

G

G

G

G

G

G

G

G

G

G

A

A

8

109

C

C

T

T

T

T

T

T

T

T

T

T

C

9

112

T

T

T

G

G

G

G

G

G

G

G

A

T

10

115

C

C

C

C

T

T

T

T

T

T

G

C

C

10

117

G

G

G

G

C

C

C

C

C

C

G

G

G

11

118

C

C

C

G

T

T

T

T

T

T

G

G

G

11

119

C

C

T

T

C

C

C

C

C

C

T

A

G

12

122

A

A

A

A

C

C

C

C

C

C

A

A

A

13

124

A

A

T

C

T

T

G

T

TG

G

T

T

T

13

125

G

G

T

A

C

C

G

C

CG

G

T

T

A

13

126

G

G

T

T

T

T

T

T

T

T

T

T

T

14

127

G

G

G

G

G

G

G

G

G

G

G

G

A

14

129

G

G

A

G

G

G

G

G

G

G

G

G

G

16

133

C

C

C

C

C

C

T

C

CT

T

C

C

C

19

144

T

T

T

C

T

T

T

T

T

T

C

C

C

26

164

T

T

T

T

AT

T

T

T

T

T

T

A

T

26

165

C

C

G

C

C

C

A

C

C

C

G

T

C

28

169

G

G

G

G

G

G

G

G

G

G

G

C

G

28

171

C

C

A

C

CG

C

G

CG

CG

C

A

C

A

30

175

T

T

T

T

T

T

C

T

T

T

C

G

C

30

176

A

A

G

A

A

A

A

A

A

A

G

G

T

31

178

T

T

A

T

T

T

T

T

T

T

G

A

T

32

181

T

T

T

T

C

CT

C

CT

CT

CT

C

T

T

33

184

A

A

A

C

A

A

A

A

A

A

A

A

A

34

189

G

G

A

A

G

AG

G

AG

AG

AG

A

A

G

37

196

T

T

T

T

AT

AT

CT

AT

AT

T

T

A

T

37

197

C

C

C

AC

AT

AT

T

AT

AT

AT

A

A

T

38

199

G

G

G

G

G

G

C

G

G

G

G

G

G

38

200

T

T

T

T

T

T

T

T

T

T

C

T

T

47

227

T

AT

A

AT

AT

AT

T

AT

AT

A

A

A

A

53

246

G

G

G

G

G

G

G

G

G

G

G

G

A

57

256

G

G

G

AG

G

G

G

AG

AG

AG

G

G

G

57

257

A

A

A

AG

A

A

AT

ATG

AC

ATG

A

T

T

57

258

CT

C

T

CT

T

T

CT

CT

CT

CT

T

C

C

58

260

C

C

C

C

C

A

C

C

C

C

C

C

C

58

261

CT

T

C

CTG

CG

G

C

CT

CTG

CG

C

C

C

60

265

T

T

T

T

T

T

T

T

CT

T

T

T

T

60

266

A

A

A

A

A

A

AC

AC

A

A

A

C

C

60

267

A

A

A

A

A

A

A

A

A

A

A

A

A

67

286

AC

ACT

AC

ACT

C

ACT

AT

ACT

ACT

AT

C

T

A

69

294

AG

A

G

AG

G

AG

A

A

AG

A

G

G

G

70

295

CG

G

C

CG

C

CG

G

G

CG

G

C

C

G

70

296

A

A

A

A

A

A

A

A

AG

A

G

G

A

70

297

G

C

G

CG

G

CG

C

C

CG

C

G

G

C

71

298

AG

A

AG

AG

A

AG

A

AG

AG

A

A

A

A

71

299

C

G

ACG

AG

A

AG

G

AG

AG

G

G

G

G

72

303

G

CG

G

G

G

G

CG

CG

G

G

CT

G

G

73

305

C

C

C

C

G

C

C

C

C

C

C

C

G

74

307

G

G

G

CG

C

CG

G

CG

CG

CG

G

G

C

74

308

C

C

C

ACT

AG

ACT

C

CT

ACT

CT

C

A

A

77

317

C

C

AC

AC

A

C

C

C

AC

C

C

C

C

77

318

C

C

CT

C

CT

C

C

C

C

C

C

C

C

78

320

A

A

A

A

A

A

A

A

A

A

A

T

AT

78

321

C

C

CT

C

C

CT

CT

C

CT

C

C

G

CG

85

341

T

T

CT

T

T

CT

CT

T

T

T

T

T

T

86

344

TG

T

TG

TG

TG

TG

G

TG

TG

TG

TG

T

T

90

357

A

A

A

AG

A

AG

A

AG

A

AG

A

A

A

93

365

C

C

C

C

C

C

C

C

C

C

C

A

C

95

372

C

C

T

C

C

C

C

C

C

C

T

C

C

96

373

C

C

G

T

C

C

C

C

C

C

C

C

C

96

374

A

A

A

A

A

A

A

A

A

A

A

A

A

96

375

A

A

G

T

T

T

T

T

T

T

A

T

T

98

379

A

A

A

G

A

A

A

A

A

A

A

G

G

101

388

G

G

G

G

G

G

G

G

G

G

G

G

G

101

389

T

T

T

T

T

T

T

T

T

T

T

T

T

101

390

A

A

G

G

G

G

G

G

G

G

G

G

G

104

397

T

T

T

G

T

T

T

T

T

T

T

G

G

106

405

C

C

C

C

C

C

C

C

C

C

C

T

T

114

429

C

C

C

C

C

C

C

C

CG

C

C

C

C

117

438

C

C

C

C

T

T

T

T

T

T

T

C

C

120

446

G

G

G

A

G

G

G

G

G

G

A

G

G

133

484

C

C

C

C

C

C

C

C

C

C

C

C

C

133

485

T

T

G

G

G

G

G

G

G

G

G

G

G

133

486

G

G

G

G

G

G

G

G

G

G

G

G

G

134

489

C

C

C

C

T

T

T

T

T

T

C

C

C

140

505

G

G

G

A

A

A

A

A

A

A

A

G

G

142

511

A

A

G

G

G

G

G

G

G

G

G

G

G

142

512

T

T

T

T

T

T

T

T

T

T

T

T

T

142

513

G

G

G

G

G

G

G

G

G

G

G

G

G

145

522

A

A

A

A

A

A

G

A

A

A

G

A

A

149

534

G

G

G

G

C

C

C

C

C

C

G

G

G

152

543

C

C

T

C

C

C

C

C

C

C

C

C

C

166

583

C

C

C

C

C

C

C

C

C

C

C

C

C

166

584

G

G

G

G

G

G

G

G

G

G

A

G

G

166

585

A

A

G

G

G

G

G

G

G

G

G

G

G

169

594

G

G

G

G

G

G

G

G

G

G

G

A

A

179

624

C

C

T

C

C

C

C

C

C

C

T

T

T

180

625

G

G

G

C

G

G

G

G

G

G

G

G

G

181

629

C

C

C

C

C

C

C

C

C

C

T

T

T

181

630

A

A

G

G

A

A

A

A

A

A

G

G

G

190

656

A

A

A

A

A

A

A

A

A

T

A

A

A

207

707

T

T

C

C

T

T

T

T

T

T

T

T

T

218

739

C

C

C

C

C

C

C

C

C

C

C

C

T

232

783

A

A

A

A

A

A

A

A

A

A

C

A

A

234

789

C

C

C

C

G

G

G

G

G

C

C

C

C

#Cases:

 

3994

208

1396

1982

1873

1068

146

1519

243

408

80

98

1653

  1. Note that many SNPs have more than two nucleotides and some SNPs have several nucleotides for the same allelic group. For instance, Nucleotide 257 can be either A or T within allelotype *12 and A, T, or G within allelotype *13. Given the high prevalence of the HLA-DRB1*15 (15) allele, the nucleotide found in this group of alleles was used as the reference, unless several nucleotides were found in the alleles constituting the HLA-DRB1*15 group.