Volume 8 Supplement 1

The Framingham Heart Study 100,000 single nucleotide polymorphisms resource

Research

Edited by Emelia J Benjamin, Caroline S Fox, Daniel J Gottlieb, Cashell E Jaquish, Daniel Levy, James B Meigs, Christopher Newton-Cheh, Christopher J O'Donnell and Ramachandran S Vasan

  1. Introduction

    The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports

    The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the world. Many collected ...

    L Adrienne Cupples, Heather T Arruda, Emelia J Benjamin, Ralph B D'Agostino, Serkalem Demissie, Anita L DeStefano, Josée Dupuis, Kathleen M Falls, Caroline S Fox, Daniel J Gottlieb, Diddahally R Govindaraju, Chao-Yu Guo, Nancy L Heard-Costa, Shih-Jen Hwang, Sekar Kathiresan, Douglas P Kiel…

    BMC Medical Genetics 2007 8(Suppl 1):S1

    Published on: 19 September 2007

  2. Research

    Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study

    Echocardiographic left ventricular (LV) measurements, exercise responses to standardized treadmill test (ETT) and brachial artery (BA) vascular function are heritable traits that are associated with cardiovasc...

    Ramachandran S Vasan, Martin G Larson, Jayashri Aragam, Thomas J Wang, Gary F Mitchell, Sekar Kathiresan, Christopher Newton-Cheh, Joseph A Vita, Michelle J Keyes, Christopher J O'Donnell, Daniel Levy and Emelia J Benjamin

    BMC Medical Genetics 2007 8(Suppl 1):S2

    Published on: 19 September 2007

  3. Research

    Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness

    About one quarter of adults are hypertensive and high blood pressure carries increased risk for heart disease, stroke, kidney disease and death. Increased arterial stiffness is a key factor in the pathogenesis...

    Daniel Levy, Martin G Larson, Emelia J Benjamin, Christopher Newton-Cheh, Thomas J Wang, Shih-Jen Hwang, Ramachandran S Vasan and Gary F Mitchell

    BMC Medical Genetics 2007 8(Suppl 1):S3

    Published on: 19 September 2007

  4. Research

    Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study

    Subclinical atherosclerosis (SCA) measures in multiple arterial beds are heritable phenotypes that are associated with increased incidence of cardiovascular disease. We conducted a genome-wide association stud...

    Christopher J O'Donnell, L Adrienne Cupples, Ralph B D'Agostino, Caroline S Fox, Udo Hoffmann, Shih-Jen Hwang, Erik Ingellson, Chunyu Liu, Joanne M Murabito, Joseph F Polak, Philip A Wolf and Serkalem Demissie

    BMC Medical Genetics 2007 8(Suppl 1):S4

    Published on: 19 September 2007

  5. Research

    Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes

    Cardiovascular disease (CVD) and its most common manifestations – including coronary heart disease (CHD), stroke, heart failure (HF), and atrial fibrillation (AF) – are major causes of morbidity and mortality....

    Martin G Larson, Larry D Atwood, Emelia J Benjamin, L Adrienne Cupples, Ralph B D'Agostino, Caroline S Fox, Diddahally R Govindaraju, Chao-Yu Guo, Nancy L Heard-Costa, Shih-Jen Hwang, Joanne M Murabito, Christopher Newton-Cheh, Christopher J O'Donnell, Sudha Seshadri, Ramachandran S Vasan, Thomas J Wang…

    BMC Medical Genetics 2007 8(Suppl 1):S5

    Published on: 19 September 2007

  6. Research

    A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study

    Breast and prostate cancer are two commonly diagnosed cancers in the United States. Prior work suggests that cancer causing genes and cancer susceptibility genes can be identified.

    Joanne M Murabito, Carol L Rosenberg, Daniel Finger, Bernard E Kreger, Daniel Levy, Greta Lee Splansky, Karen Antman and Shih-Jen Hwang

    BMC Medical Genetics 2007 8(Suppl 1):S6

    Published on: 19 September 2007

  7. Research

    Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study

    Heritable electrocardiographic (ECG) and heart rate variability (HRV) measures, reflecting pacemaking, conduction, repolarization and autonomic function in the heart have been associated with risks for cardiac...

    Christopher Newton-Cheh, Chao-Yu Guo, Thomas J Wang, Christopher J O'Donnell, Daniel Levy and Martin G Larson

    BMC Medical Genetics 2007 8(Suppl 1):S7

    Published on: 19 September 2007

  8. Research

    Genome-wide association of sleep and circadian phenotypes

    Numerous studies suggest genetic influences on sleepiness and circadian rhythms. The Sleep Heart Health Study collected questionnaire data on sleep habits and sleepiness from 2848 Framingham Heart Study Offspr...

    Daniel J Gottlieb, George T O'Connor and Jemma B Wilk

    BMC Medical Genetics 2007 8(Suppl 1):S9

    Published on: 19 September 2007

  9. Research

    A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study

    Glomerular filtration rate (GFR) and urinary albumin excretion (UAE) are markers of kidney function that are known to be heritable. Many endocrine conditions have strong familial components. We tested for asso...

    Shih-Jen Hwang, Qiong Yang, James B Meigs, Elizabeth N Pearce and Caroline S Fox

    BMC Medical Genetics 2007 8(Suppl 1):S10

    Published on: 19 September 2007

  10. Research

    Genome-wide association with select biomarker traits in the Framingham Heart Study

    Systemic biomarkers provide insights into disease pathogenesis, diagnosis, and risk stratification. Many systemic biomarker concentrations are heritable phenotypes. Genome-wide association studies (GWAS) provi...

    Emelia J Benjamin, Josée Dupuis, Martin G Larson, Kathryn L Lunetta, Sarah L Booth, Diddahally R Govindaraju, Sekar Kathiresan, John F Keaney, Michelle J Keyes, Jing-Ping Lin, James B Meigs, Sander J Robins, Jian Rong, Renate Schnabel, Joseph A Vita, Thomas J Wang…

    BMC Medical Genetics 2007 8(Suppl 1):S11

    Published on: 19 September 2007

  11. Research

    Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study

    Increased circulating levels of hemostatic factors as well as anemia have been associated with increased risk of cardiovascular disease (CVD). Known associations between hemostatic factors and sequence variant...

    Qiong Yang, Sekar Kathiresan, Jing-Ping Lin, Geoffrey H Tofler and Christopher J O'Donnell

    BMC Medical Genetics 2007 8(Suppl 1):S12

    Published on: 19 September 2007

  12. Research

    Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

    Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span.

    Kathryn L Lunetta, Ralph B D'Agostino, David Karasik, Emelia J Benjamin, Chao-Yu Guo, Raju Govindaraju, Douglas P Kiel, Margaret Kelly-Hayes, Joseph M Massaro, Michael J Pencina, Sudha Seshadri and Joanne M Murabito

    BMC Medical Genetics 2007 8(Suppl 1):S13

    Published on: 19 September 2007

  13. Research

    Genome-wide association with bone mass and geometry in the Framingham Heart Study

    Osteoporosis is characterized by low bone mass and compromised bone structure, heritable traits that contribute to fracture risk. There have been no genome-wide association and linkage studies for these traits...

    Douglas P Kiel, Serkalem Demissie, Josée Dupuis, Kathryn L Lunetta, Joanne M Murabito and David Karasik

    BMC Medical Genetics 2007 8(Suppl 1):S14

    Published on: 19 September 2007

  14. Research

    Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham study

    Brain magnetic resonance imaging (MRI) and cognitive tests can identify heritable endophenotypes associated with an increased risk of developing stroke, dementia and Alzheimer's disease (AD). We conducted a ge...

    Sudha Seshadri, Anita L DeStefano, Rhoda Au, Joseph M Massaro, Alexa S Beiser, Margaret Kelly-Hayes, Carlos S Kase, Ralph B D'Agostino, Charles DeCarli, Larry D Atwood and Philip A Wolf

    BMC Medical Genetics 2007 8(Suppl 1):S15

    Published on: 19 September 2007

  15. Research

    Genome-wide association with diabetes-related traits in the Framingham Heart Study

    Susceptibility to type 2 diabetes may be conferred by genetic variants having modest effects on risk. Genome-wide fixed marker arrays offer a novel approach to detect these variants.

    James B Meigs, Alisa K Manning, Caroline S Fox, Jose C Florez, Chunyu Liu, L Adrienne Cupples and Josée Dupuis

    BMC Medical Genetics 2007 8(Suppl 1):S16

    Published on: 19 September 2007

  16. Research

    A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study

    Blood lipid levels including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are highly heritable. Genome-wide association is a promising appro...

    Sekar Kathiresan, Alisa K Manning, Serkalem Demissie, Ralph B D'Agostino, Aarti Surti, Candace Guiducci, Lauren Gianniny, Nöel P Burtt, Olle Melander, Marju Orho-Melander, Donna K Arnett, Gina M Peloso, Jose M Ordovas and L Adrienne Cupples

    BMC Medical Genetics 2007 8(Suppl 1):S17

    Published on: 19 September 2007

  17. Research

    Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project

    Obesity is related to multiple cardiovascular disease (CVD) risk factors as well as CVD and has a strong familial component. We tested for association between SNPs on the Affymetrix 100K SNP GeneChip and measu...

    Caroline S Fox, Nancy Heard-Costa, L Adrienne Cupples, Josée Dupuis, Ramachandran S Vasan and Larry D Atwood

    BMC Medical Genetics 2007 8(Suppl 1):S18

    Published on: 19 September 2007