From: Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A
Allele Freq (T) | HWE | Additive | P value | Dominant C (Gly) | P value | Dominant T (Ser) | P value | Heterozygous Advantage | P value | |
---|---|---|---|---|---|---|---|---|---|---|
Linear regression between BMI and rs8192678 under the 4 genetic models. Beta (95% CI) | ||||||||||
NZ Caucasian | 0.346 | 0.728 | 0.319 (−0.198, 0.835) | 0.227 | −0.555 (−1.618, 0.507) | 0.305 | 0.350 (−0.358, 1.058) | 0.332 | 0.102 (−0.601, 0.806) | 0.775 |
NZ Māori | 0.806 | 0.721 | 0.629 (−0.848, 2.106) | 0.403 | −0.837 (−2.588, 0.913) | 0.347 | 0.263 (−3.885, 4.412) | 0.901 | −0.831 (−2.625, 0.964) | 0.363 |
CI Māori | 0.805 | 1.000 | 0.612 (−2.342, 3.566) | 0.682 | −0.627 (−3.940, 2.686) | 0.709 | 1.319 (−8.733, 11.371) | 0.795 | −0.504 (−3.886, 2.879) | 0.769 |
Samoan | 0.688 | 0.043 | −0.610 (−2.605, 1.386) | 0.548 | 0.705 (−1.757, 3.166) | 0.573 | −0.873 (−5.749, 4.002) | 0.724 | 0.487 (−1.989, 2.964) | 0.698 |
Tongan | 0.636 | 0.310 | 0.755 (−0.958, 2.468) | 0.384 | −0.895 (−3.382, 1.592) | 0.477 | 1.336 (−2.118, 4.791) | 0.445 | −0.218 (−2.799, 2.363) | 0.867 |
Polynesian | 0.747 | 0.925 | 0.345 (−0.611, 1.300) | 0.479 | −0.408 (−1.587, 0.770) | 0.496 | 0.470 (−1.904, 2.843) | 0.698 | −0.301 (−1.496, 0.895) | 0.621 |
Logistic regression between gout affection and rs8192678. OR (95% CI) | ||||||||||
NZ Caucasian | 0.346 | 0.728 | 0.846 (0.683, 1.047) | 0.125 | 1.290 (0.828, 1.996) | 0.256 | 0.819 (0.612, 1.095) | 0.180 | 0.916 (0.686, 1.221) | 0.548 |
NZ Māori | 0.806 | 0.721 | 1.238 (0.737, 2.111) | 0.425 | 0.896 (0.488, 1.635) | 0.721 | 3.644 (0.697, 28.949) | 0.159 | 1.071 (0.578, 1.977) | 0.827 |
CI Māori | 0.805 | 1.000 | 0.785 (0.361, 1.654) | 0.529 | 1.126 (0.488, 2.611) | 0.780 | - | - | 0.936 (0.397, 2.202) | 0.879 |
Samoan | 0.688 | 0.043 | 1.110 (0.638, 1.933) | 0.711 | 1.097 (0.543, 2.220) | 0.796 | 2.328 (0.658, 8.556) | 0.189 | 1.437 (0.707, 2.975) | 0.320 |
Tongan | 0.636 | 0.310 | 1.073 (0.562, 2.039) | 0.829 | 1.248 (0.477, 3.310) | 0.651 | 1.911 (0.543, 6.737) | 0.308 | 1.991 (0.713, 5.971) | 0.199 |
Polynesian | 0.747 | 0.925 | 1.149 (0.862, 1.533) | 0.345 | 0.970 (0.678, 1.385) | 0.865 | 2.024 (1.005, 4.126) | 0.049 | 1.170 (0.814, 1.685) | 0.396 |
Logistic regression between T2D and rs8192678. OR (95% CI) | ||||||||||
NZ Caucasian | 0.346 | 0.728 | 1.046 (0.767, 1.419) | 0.774 | 0.953 (0.523, 1.835) | 0.880 | 1.065 (0.700, 1.630) | 0.771 | 1.041 (0.686, 1.576) | 0.850 |
NZ Māori | 0.806 | 0.721 | 0.768 (0.463, 1.294) | 0.311 | 1.362 (0.737, 2.495) | 0.319 | 0.706 (0.181, 3.535) | 0.636 | 1.299 (0.692, 2.407) | 0.409 |
CI Māori | 0.805 | 1.000 | 2.280 (0.901, 6.410) | 0.096 | 0.348 (0.111, 0.977) | 0.054 | 0.647 (0.037, 20.494) | 0.777 | 0.314 (0.095, 0.910) | 0.042 |
Samoan | 0.688 | 0.043 | 1.307 (0.630, 2.814) | 0.480 | 0.788 (0.329, 1.886) | 0.590 | 2.043 (0.316, 40.719) | 0.527 | 0.904 (0.379, 2.142) | 0.818 |
Tongan | 0.636 | 0.310 | 1.063 (0.477, 2.443) | 0.882 | 0.961 (0.328, 2.888) | 0.942 | 1.198 (0.233, 9.316) | 0.841 | 1.030 (0.342, 3.045) | 0.957 |
Polynesian | 0.747 | 0.925 | 1.738 (0.768, 4.219) | 0.200 | 0.911 (0.610, 1.335) | 0.646 | 1.104 (0.476, 2.901) | 0.827 | 0.928 (0.617, 1.386) | 0.716 |