Fig 1

Hierarchical clustering and multi-dimensional scaling of individuals. a: Hierarchical clustering using genome-wide IBD in GENEMSA and the WTCCC2 dataset. The dendrogram demonstrates relationship between individuals and the lower bars designate assigned population of each individual. Control Ashkenazi Jews (AJ) corresponds to ethnically well-characterized Ashkenazi controls [9]. The lower panel shows individual ancestry and admixture proportions with K = 3. b: Multidimensional scaling of genome-wide IBD in GENEMSA and WTCCC2 dataset (pink = previously well defined AJ controls [9], green = newly defined AJ cases and controls, yellow = EUNW, blue = EUS)