Table 5 Nominally significant associations in the New York state cohort - secondary hypotheses
From: Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects
Gene SNP | Race/ Ethnicity | Freq Risk Allele | NTD | Test/Model | GRR [95% CI], p-value |
|---|---|---|---|---|---|
ALDH1A2 rs7169289 | AA | 0.17 | Isolated NTDs | LR Cont | 0.57 [0.34-0.98], p = 0.041 |
ARID1A rs11247593 | NHW | 0.75 | All NTDs | LR Dom | 0.58 [0.35-0.97], p = 0.037 |
ALDH1A2 rs7169289 | AA | 0.17 | Isolated SB | LR Cont | 0.46 [0.25-0.87], p = 0.017 |
ALDH1A2 rs7169289 | AA | 0.17 | Isolated SB | LR Dom | 0.47 [0.24-0.94], p = 0.033 |