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Table 2 Additive genotype-by-diabetes interaction for obesity related quantitative traits in American Indian participants of the Strong Heart Family Study

From: Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study

    

Genetic standard deviation

Obesity traits

Variance due to covariates*

Residual kurtosis after covariates

Genetic correlation (ρG) ± SE among diabetics and nondiabetics (P-value)

Diabetic individuals

Non-diabetic individuals

P-value**

Weight

0.11

0.55

0.56 ± 0.16 (0.01)

15.56

18.83

0.26

BMI

0.09

0.75

0.45 ± 0.17 (0.0002)

6.26

5.56

0.50

% FAT

0.47

0.96

0.67 ± 0.18 (0.08)

5.58

7.46

0.16

WHR†

0.22

0.57

0.72 ± 0.15 (0.02)

5.77

5.51

0.77

  1. BMI, body mass index; WHR, waist-to-hip ratio; FAT, body fat; SE, standard error. * age, sex, center; ** P-values for the likelihood ratio comparing a model in which the genetic variances for obesity traits in diabetics and non-diabetics are equal to a model without constrains. †The trait was scaled by multiplying by 100.
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BMC Medical Genetics

ISSN: 1471-2350

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